2019 Molecular Developmental Biology and Evolution

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Academic unit or major
Graduate major in Life Science and Technology
Instructor(s)
Kume Shoen  Kawakami Atsushi  Tanaka Mikiko  Kajikawa Masaki  Nikaido Masato 
Course component(s)
Lecture
Day/Period(Room No.)
Tue3-4(J221,S223)  Fri3-4(J221,S223)  
Group
-
Course number
LST.A406
Credits
2
Academic year
2019
Offered quarter
3Q
Syllabus updated
2019/4/5
Lecture notes updated
-
Language used
English
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Course description and aims

The aim of this class is to understand the advanced subjects of developmental and regenerative biology and evolutionary biology. Students will understand the processes and regulatory mechanisms of animal development and organ formation, and further learn the relationship with applied technologies such as genetic engineering and stem cells. Moreover, students will also learn and understand the evolutionary processes of animal morphologies and genome information. Lectures will cover from basic to advanced levels.

Student learning outcomes

By the end of this course, students will be able to:
1) Understand the processes and mechanisms of organs derived from the mesoderm.
2) Understand the evolution of developmental processes.
3) Understand the processes and mechanisms of several organs derived from the mesoderm.
4) Understand the molecular background of animal development and principles of genetic engineering.
5) Understand the stem cells and its application to tissue regeneration.
6) Understand the mechanisms of genome evolution.
7) Understand the tissue homeostasis and regeneration.

Keywords

Development, Organ formation, Evolution, Mesoderm, Endoderm, Genetic engineering, Stem cells, Tissue homeostasis, Regeneration

Competencies that will be developed

Intercultural skills Communication skills Specialist skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Active participation of individual students is necessary When required, students will be given a small test or report as an index of purpose achievement. These will be used for academic assessment. Lectures are basically given in English, but Japanese and other languages will be used depending on the student's level of understanding and necessity.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Organ formationⅠ: Development of mesoderm-derived organs 1 - heart, vessels and blood cells (Tanaka, Mikiko) Understand the development of mesoderm-derived organs. Specific instructions will be given in each class.
Class 2 Organ formationⅡ: Development of mesoderm-derived organs 2 - somites and limbs(Tanaka, Mikiko) Understand the development of mesoderm-derived organs.Specific instructions will be given in each class.
Class 3 Organ formation III:Development of ectoderm-derived organs 3 - ectodermal derivatives (Tanaka, Mikiko) Understand the development of mesoderm-derived organs. Specific instructions will be given in each class.
Class 4 Evolution and development   (Tanaka, Mikiko) Understand the evolution of developmental processes. Specific instructions will be given in each class.
Class 5 Organ formation IV: Developmental processes of endoderm-derived organs 1 (Kume, Shoen) Understand the developmental processes of endoderm-derived organs.Specific instructions will be given in each class.
Class 6 Organ formation V: Developmental processes of endoderm-derived organs 2 (Kume, Shoen) Understand the developmental and stem cell biology. Specific instructions will be given in each class.
Class 7 Developmental biology and stem cell biology (Kume, Shoen) Understand the developmental mechanisms and the principle of genetic engineering. Specific instructions will be given in each class.
Class 8 Developmental biology and stem cell biology (Kume, Shoen) Understand the stem cells and tissue regeneration. Specific instructions will be given in each class.
Class 9 Evolutionary Concept (Masato Nikaido) Understand the evolution of sex and recombination. Specific instructions will be given in each class.
Class 10 Evolution of Whales and Dolphins (Nikaido) Understand the genome evolution of eukaryotes. Specific instructions will be given in each class.
Class 11 Evolution of Coelacanth (Nikaido) Understand the genome evolution of eukaryotes. Specific instructions will be given in each class.
Class 12 Evolutionary History III: Evolution of Cichlids (Neotropical fish) (Nikaido) Understand the evolutionary history of human.Specific instructions will be given in each class.
Class 13 Tissue homeostasis 101 (Kawakami, Atsushi) Understand the basic concept and examples of tissue homeostasis.Specific instructions will be given in each class.
Class 14 Science lesson I (Kawakami, Atsushi) Understand the molecular background of tissue homeostasis.Specific instructions will be given in each class.
Class 15 Science lesson II (Kawakami, Atsushi) Understand the cellular basis of tissue homeostasis.Specific instructions will be given in each class.

Textbook(s)

None.

Reference books, course materials, etc.

Course materials will be provided during class or through OCW-I as the need arises.

Assessment criteria and methods

Academic assessment will be done by the scores of small test and/or the performance in the class if necessary. When we lecturers think it is necessary, the term-end examination will be conducted.

Related courses

  • LST.A344 : Animal Physiology
  • LST.A335 : Molecular Genetics
  • LST.A346 : Basic Neuroscience
  • LST.A362 : Evolution and Developmental Biology

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Genetics, Evolution and Developmental biology, Animal phisiology, Molecular physiology.

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