How deep knowledge or useful information can we retrieve from diverse and enormous data obtain from multi-omics analysis? This course forcuses on Bioinformatics. Topics includes molecular evolution, sequence analysis, comparative genomics, multi-omics analysis, algorithms for bioinformatics, molecular or metabolic network analysis, and data mining methods. By combining lectures and exercises, the course enables students to understand and acquire the fundamentals of bioinformatics widely applicable to biological research. Bioinformatic approaches taught in this course are not only useful in analyzing multi-omics data, but are applicable to various other types of biological problem.
By the end of this course, students will be able to:
1) Understand principles and methods of sequence analysis based on molecular evolution
2) Understand the knowledge obtained by comparing the gene sequences and genomic sequences
3) Understand computer algorithms in bioinformatic analyses
4) Understand the fundamentals and applications of multi- omics analysis
5) Understanding of basics and applications of molecular dynamics simulation
|✔ Specialist skills||Intercultural skills||Communication skills||Critical thinking skills||Practical and/or problem-solving skills|
Required learning should be completed outside of the classroom for preparation and review purposes.
|Course schedule||Required learning|
|Class 1||Overview of classical biomolecular simulation||Understanding of overview of classical biomolecular simulation|
|Class 2||Model building of biomolecules (molecular mechanics, etc)||Understanding of molecular mechanics|
|Class 3||Classical biomolecular simulation||Understanding of molecular dynamics simulation|
|Class 4||Applications of simulation and analysis||Understanding of applications of simulation and analysis of the obtained results.|
|Class 5||Computer modeling of biomolecules||Understanding of computer modeling of biomolecules using molecular simulation|
|Class 6||Overview of fundamental bioinformatics||Understanding of overview of fundamental bioinformatics|
|Class 7||Basics of omics data analysis||Understanding of omics data analysis|
|Class 8||Metagenomics for microbiome||Understanding of metagenomics|
|Class 9||Applications of metagenomics for human gut microbiome||Understanding of applications of metagenomics|
|Class 10||Basics of machine learning for omics data||Understanding of machine learning for omics data|
|Class 11||Fundamentals of Next Generation Sequencers||Understand the fundamentals of Next Generation Sequencers|
|Class 12||Application of Next Generation Sequencers 1||Understand the application of Next Generation Sequencers 1|
|Class 13||Application of Next Generation Sequencers 2||Understand the application of Next Generation Sequencers 2|
|Class 14||Application of Next Generation Sequencers 3||Understand the application of Next Generation Sequencers 3|
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Neil C. Jones and Pavel A. Pevzner. An Introduction to Bioinformatics Algorithms. ISBN-13: 978-0262101066
Masatoshi Nei and Sudhir Kumar. Molecular Evolution and Phylogenetics. ISBN-13: 978-0195135855
By written reports for each class.
Basic level of physical chemistry (quantum chemistry and classical mechanics)
Basic level of mathematics (calculus and linear algebra)
Basic level of statistical physics
Basic level of genomics