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- 工学院，物質理工学院，環境・社会理工学院共通科目
- Liberal arts and basic science courses
- First-Year Courses
- School of Science
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School of Environment and Society
- Department of Architecture and Building Engineering
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- Graduate major in Technology and Innovation Management
- Common courses
- Liberal arts and basic science courses
- Academic unit or major
- Undergraduate major in Life Science and Technology
- Instructor(s)
- Nakamura Nobuhiro Kawakami Atsushi Shiraki Nobuaki Tagawa Yoh-Ichi
- Class Format
- Lecture (Face-to-face)
- Media-enhanced courses
- Day/Period(Room No.)
- Mon7-8(M-178(H1101)) Thr7-8(M-178(H1101))
- Group
- -
- Course number
- LST.A344
- Credits
- 2
- Academic year
- 2024
- Offered quarter
- 2Q
- Syllabus updated
- 2024/3/14
- Lecture notes updated
- -
- Language used
- Japanese
- Access Index
-
Course description and aims
Animal physiology is the fundamental study that helps us better understand human health and disease.
This course facilitates students’ understanding of the history of development of life science and the significance of life science in modern science. The aim of this course is for students to understand the basic concepts and mechanisms of how multicellular animals maintain homeostasis. This course also aims for students to understand molecular mechanisms of 1) the endocrine system that detects and responses to changes in internal environment of the body and 2) the immune system that recognizes and eliminates foreign substances and organisms, such as pathogens.
Student learning outcomes
At the end of this course, students will be able to:
1) Understand the mechanism and principle of tissue homeostasis and organ regeneration in multicellular organisms.
2) Explain endocrine regulation of homeostasis and its signaling mechanisms.
3) Explain the basic concepts of the immunological defense system.
Keywords
Tissue homeostasis, Regeneration, Development, Immunology, Endocrine, Metabolism
Competencies that will be developed
| ✔ Specialist skills | Intercultural skills | Communication skills | Critical thinking skills | Practical and/or problem-solving skills |
Class flow
Students may be given written tests or reports. The score of tests/reports will be used for academic assessment.
Course schedule/Required learning
| Course schedule | Required learning | |
|---|---|---|
| Class 1 | The basics of regenerative biology (Kawakami) | Learn the basics of regenerative biology. Preparation and review of the lecture are strongly recommended. |
| Class 2 | Signals for tissue regeneration (Kawakami) | Learn the molecular signals and their actions during regeneration. Preparation and review of the lecture are strongly recommended. |
| Class 3 | Cell lineage that assists regeneration (Regeneration of bone) (Kawakami) | Learn the origin and fate of regenerating cells (in bone). Preparation and review of the lecture are strongly recommended. |
| Class 4 | Positional information during regeneration (Kawakami) Mid-term examination (class 1-4) | Understand the concept of positional information and its involvement in tissue regeneration. Preparation and review of the lecture are strongly recommended. Evaluate the understanding of Classes 1-4. |
| Class 5 | What is the endocrine system? Endocrine system vs. nervous system (Shiraki) | Understand basic issues of the endocrine system. Preparation and review of the textbook are strongly recommended. |
| Class 6 | Hormones, receptors, and signal transduction (Shiraki) | Understand the relationship between the hormone and hormone receptors and hormone-mediated signal transduction. Preparation and review of the textbook are strongly recommended. |
| Class 7 | Physiological roles of hormones (1): Stress response and control of blood glucose levels (Shiraki) | Understand stress-induced hormone secretion and hormone-mediated glucose metabolism. Preparation and review of the textbook are strongly recommended. |
| Class 8 | Physiological roles of hormones (2): Body fluid regulation Review (class ＃5-8) & Mid-term examination (Shiraki) | Understand the mechanisms of body fluids regulation through the renin-angiotensin-aldosterone system. Evaluate the understanding of Classes 5-8. |
| Class 9 | The mechanism of generating antibody diversity (Nakamura) | Understand the mechanism of antibody diversity (immunoglobulins). Preparation and review of the textbook (chapter 25) is strongly recommended. |
| Class 10 | Overview of the process from antigen presentation to antibody production (Nakamura) | Understand the process from antigen presentation to antibody production. Preparation and review of the textbook (chapter 25) is strongly recommended. |
| Class 11 | Infection and inflammation (Tagawa) | Understand infections of microbes, including viruses, bacteria and parasites, and the inflammation caused by these infections. Preparation and review of the textbook are strongly recommended. |
| Class 12 | Innate and acquired immunity (Tagawa) | Understand innate and acquired immunity, which is the host's defense against infection. Preparation and review of the textbook are strongly recommended. |
| Class 13 | Immunological studies using developmental engineering technology (Tagawa) | Understand immunological studies using transgenic and gene knockout animals. Preparation and review of the textbook are strongly recommended. |
| Class 14 | Animal models of autoimmune diseases & Examination (Tagawa) | Understand autoimmune disease studies using their model animals. Preparation and review of the textbook are strongly recommended. Evaluate the understanding of Classes 11-14. |
Out-of-Class Study Time (Preparation and Review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
（Class 1-4）Lewis Wolpert, Cheryll Tickle, Developmental Biology (Medical Science International), ISBN978-4895927161
（Class 5-10) Donald Voet, Judith G.Voet, BIOCHEMISTRY (Tokyo Kagaku Dozin) Part 16-19, ISBN978-4-8079-0807-3
（Class 9-12）Bruce Albert et al., Molecular Biology of the Cell, 5th Edition (Newton Press) Chapter 24-25, ISBN978-4-315-
51867-2
Reference books, course materials, etc.
Course materials will be provided during class or through T2SCHOLA as the need arises.
（Class5-8) Kazuwa Nakano 『SAISHIN NAIBUNPITSUTAISHYAGAKU』 (SHINDAN TO CHIRYO SHA) (in Japanease), ISBN978-4-7878-1937-6
（Class9-14）『JANEWAY'S Immunobiology』 Nankodo
Assessment criteria and methods
Academic assessment will be done by the scores of written tests and/or reports.
Related courses
- LST.A208 ： Molecular Biology I
- LST.A335 ： Molecular Genetics
- LST.A362 ： Evolution and Developmental Biology
- LST.A346 ： Basic Neuroscience
- LST.A406 ： Molecular Developmental Biology and Evolution
- LST.A401 ： Molecular and Cellular Biology
- LST.A404 ： Cell Physiology
- LST.A213 ： Molecular Biology II
- LST.A352 ： Cell Engineering
- LST.A421 ： Functional Life Science
Prerequisites (i.e., required knowledge, skills, courses, etc.)
Student are recommended to complete classes of 6Q and 7Q, Molecular biology 1 and 2, and 9Q Genetics.
