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- 工学院，物質理工学院，環境・社会理工学院共通科目
- Liberal arts and basic science courses
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- Liberal arts and basic science courses
- Academic unit or major
- Undergraduate major in Life Science and Technology
- Instructor(s)
- Iwasaki Hiroshi Kimura Hiroshi Nikaido Masato Aizawa Yasunori
- Class Format
- Lecture
- Media-enhanced courses
- Day/Period(Room No.)
- -
- Group
- -
- Course number
- LST.A248
- Credits
- 2
- Academic year
- 2024
- Offered quarter
- 4Q
- Syllabus updated
- 2024/3/14
- Lecture notes updated
- -
- Language used
- Japanese
- Access Index
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Course description and aims
Genetics is the study of heredity and biological diversity. It serves as the foundational science across various academic disciplines, extending beyond the fundamentals of bioscience. This course begins with the basic principles of heredity and biological diversity. It then delves into both classical concepts and the latest research topics in genetics, such as genomics, reverse genetics, synthetic biology, omics, microbial genetics, genome integrity, and epigenetics. The objective is to equip students with a comprehensive understanding of genetics, ensuring they acquire both the necessary and advanced knowledge relevant to the field.
Student learning outcomes
By the end of this course, students will be able to:
1. Explain the basic concept of genetics at molecular levels, as well as that of genomics.
2. Explain the basic molecular mechanisms of genome integrity and the creation of genetic diversity.
3. Explain epigenetics and its basic molecular mechanism.
Keywords
Mendelian inheritance, Genetic diversity, Genome, Reverse genetics, Genomics, Microbial genetics, Epigenetics, Genome integrity, DNA repair,
Competencies that will be developed
| ✔ Specialist skills | Intercultural skills | Communication skills | ✔ Critical thinking skills | Practical and/or problem-solving skills |
Class flow
For the first 10 min of each lecture, a summary of the previous lecture is given as necessary, followed by the main points of the day's lecture. For the last 15 min of each lecture, a quiz may be given to find out if students have learned the material given.
Course schedule/Required learning
| Course schedule | Required learning | |
|---|---|---|
| Class 1 | Mendelian and non-Mendelian inheritance | Students must be able to explain the theory of Menderian and non-Menderian inheritance. |
| Class 2 | Chromosome theory of inheritance: gene map and recombination | Students must be able to explain the role of chromosomes in genetic inheritance. |
| Class 3 | Forward Genetics: from phenotype to genotype | Students must be able to explain the methodology of the forward genetics and the concept of its "forwardness." |
| Class 4 | Genomic diversity. | Students must be able to explain the principles and significance of genomic diversity. |
| Class 5 | Overview of modern genomics | Students will be able to understand the history of conceptual and technological progcesses of genomics. |
| Class 6 | High-spec DNA sequencers and their applications | Students will be able to grasp pros and cons of all the main DNA sequencing technologies. |
| Class 7 | Reverse genetics: from genotype to phenotype | Students will be able to make rough plans of reverse genetic experiments. |
| Class 8 | Omics biology | Students will be able to explain the concept and methodologies of comprehensive studies of gene expression. |
| Class 9 | Microbial Genetics | Students must be able to explain the basic concept and methodologies of microbial genetics using E. coli and yeast as model organisms. |
| Class 10 | Mechanism of genome integrity | Students must be able to explain how cells maintain genome integrity and how an organism creates genetic diversity. |
| Class 11 | Sexual reproduction and meiosis | Students must be able to explain the molecular mechanism of meiosis and meiotic recombination. |
| Class 12 | Genetics and epigenetics | Students must be able to explain what is epigenetics. |
| Class 13 | Mechanism of epigenetics | Students must be able to explain the mechanism of epigenetics. |
| Class 14 | Regulation of epigenetics | Students must be able to explain the regulation of epigenetics. |
Out-of-Class Study Time (Preparation and Review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
Not specified.
Reference books, course materials, etc.
Genetics: from Genes to Genomes (Hartwell et al.) (Medical Science International), Molecular Biology of the Cell (Alberts et al.) 5th & 6th ed. (Newton Press), Molecular Cell Biology (Lodish et al.) (W H Freeman & Co.).
Assessment criteria and methods
Reports, quizzes, etc.
Related courses
- LST.A203 ： Biochemistry I
- Biochemistry II
- LST.A213 ： Molecular Biology II
- Molecular Biology II
Prerequisites (i.e., required knowledge, skills, courses, etc.)
Students must have successfully completed Biochemistry I, Biochemistry II, Molecular Biology I, and Molecular Biology II, or have equivalent knowledge.
