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2021　Enzyme Engineering

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Academic unit or major
Undergraduate major in Life Science and Technology
Instructor(s)
Matsuda Tomoko  Ichinose Hiroshi  Ogura Shunichiro 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Tue3-4(S516)  Fri3-4(S611)  
Group
-
Course number
LST.A364
Credits
2
Academic year
2021
Offered quarter
1Q
Syllabus updated
2021/3/19
Lecture notes updated
-
Language used
Japanese
Access Index

Course description and aims

Catalysts for reactions occurring in all living organisms are enzymes, so that the understanding of properties and functions of enzymes is indispensable for the understanding of life science and technology. This course covers basics and applications concerning enzymes. The knowledge of biochemistry and organic chemistry will be applied to the understand enzymes. The cutting-edge research using enzymes in the field of the medicinal, food, and environmental sciences as well as organic chemistry is also introduced. Furthermore, the opportunities to discuss, communicate and present about the field of studies are given.

The lectures about the enzyme improve your logical thinking ability, communication and presentation skills as well as help your acquirement of the technical knowledge. It is to cultivate the human resources who can lead advanced science and engineering through the studies of enzymes.

Student learning outcomes

By the end of this course, students will be able to:
(1)　Acquire the basic knowledge about enzymes and enzyme kinetics. Understand the applied studies of bioengineering related to enzyme.
(2)　Acquire the knowledge about enzymes controlling metabolism. Understand the effect of the enzymes on the diseases.
(3)　Acquire the knowledge about application of enzymes to organic chemistry.
(4)　Understand and present the recent research using enzymes in organic synthesis.

Keywords

enzyme, enzyme kinetics,
enzymes controlling metabolism,
hydrolase, oxidoreductase, coenzyme

Competencies that will be developed

✔ Specialist skills Intercultural skills ✔ Communication skills ✔ Critical thinking skills Practical and/or problem-solving skills

Class flow

Classes by Ogura and Ichinose will be lecture-style ones.　 Classes by Matsuda are interactive, and there are also group discussion opportunity. Presentation may be required at the last class by Matsuda.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Basics of enzymes (Ogura) Acquire the knowledge of basics of enzyme through general introduction
Class 2 Enzymes used in the laboratory (Ogura) Acquire the knowledge of enzymes used in the laboratory
Class 3 Drug metabolizing enzyme (Ogura) Acquire the knowledge of drug metabolizing enzyme
Class 4 Proteolytic enzymes and homeostasis (Ogura) Acquire the knowledge of Proteolytic enzymes and homeostasis
Class 5 Understanding enzymes with organic chemistry aspect (Matsuda) Apply the knowledge of organic chemistry to understand enzyme properties and function
Class 6 Cancelled (4/30) Cancelled
Class 7 Application of enzymes in the field of organic chemistry (Matsuda) Understand the applied studies of enzymes in organic chemistry
Class 8 Reaction mechanisms of hydrolase (Matsuda) Understand the mechanism of hydrolase
Class 9 Presentation (Matsuda) Group presentation and discussion
Class 10 Reaction mechanisms of oxidoreductase (Matsuda) Understand the mechanism of oxidoreductase functioning with coenzyme
Class 11 Physiological significance of the enzymes and the diseases caused by the dysfunction of the enzyme (Ichinose) Understand the physiological significance of the enzymes to maintain homeostasis, and the etiology of the diseases caused by the dysfunction of the enzyme
Class 12 Individuality caused by genetic variation of the enzymes (Ichinose) Understand the effects of genetic variations on the individual disposition
Class 13 The enzyme as a target for drugs and toxins (Ichinose) Understand that the many drugs and toxins act on the enzymatic reactions
Class 14 Vitamins and minerals in the enzyme reactions, and quiz (Ichinose) Understand the role of vitamins and minerals in the enzyme reactions Take quiz

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Handout

Reference books, course materials, etc.

Handout

Assessment criteria and methods

Students' abilities to understand the basics of enzyme engineering and their abilities to apply the basics to study enzyme and develop enzyme engineering will be assessed.
Class participation, report and quiz 1 during classes by Ogura (31%)
Class participation, presentation and report during classes by Matsuda (38%)
Class participation, report and quiz 2 during classes by Ichinose (31%)

Related courses

  • Organic chemistry I〜 IV
  • Phisical chemistry I〜 III
  • Biochemistry I, II

Prerequisites (i.e., required knowledge, skills, courses, etc.)

None

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