2019 Biomedical Materials

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Academic unit or major
Undergraduate major in Life Science and Technology
Instructor(s)
Maruyama Atsushi  Mihara Hisakazu  Tagawa Yoh-Ichi  Tsutsumi Hiroshi 
Course component(s)
Lecture
Day/Period(Room No.)
Tue3-4(W541)  Fri3-4(W541)  
Group
-
Course number
LST.A342
Credits
2
Academic year
2019
Offered quarter
2Q
Syllabus updated
2019/4/10
Lecture notes updated
-
Language used
Japanese
Access Index

Course description and aims

This course focuses on the materials used in biomedical fields. Topics include the general introduction of biomedical materials (biomaterials), biomaterials from natural sources, design and preparation of biomedical polymers, surface modification of materials and bioconjugate materials composed of biomolecules and artificially synthetic materials. By combining lectures and exercises, the course enables students to understand and acquire the fundamentals of biomaterials widely applicable to biomedical uses.
Biomaterials that are used in contact with biological components is crucially important for artificial organs, drug delivery and tissue engineering devices and diagnostic tools. Understanding of biological events occurred at interface between material surface and biological components is crucial to design biomaterials with high functionality, safety and reliability. Biomaterials design also require knowledge of material preparation, modification and characterization methods. Surface modification chemistry and bioconjugate chemistry are also important for biomaterials design. Students will learn fundamentals of biomaterials science that is necessary for biomaterial design.

Student learning outcomes

By the end of this course, students will be able to:
1) Explain the definition of biomaterials, and the roles and categories of biomaterials.
2) Explain bio-responses at material surfaces and propose ideas to design biomaterials.
3) Explain protein and polysaccharide biomaterials and their properties and functions.
4) Explain polymer biomaterials and their preparation methods, properties and functions.
5) Explain the concept of surface modification and bioconjugation and its application to biomaterials.

Keywords

Bio-interface, Naturally occurring biomaterials, Biocompatibility, Blood compatibility, Drug delivery systems, Tissue engineering, Hydrogels,

Competencies that will be developed

Intercultural skills Communication skills Specialist skills Critical thinking skills Practical and/or problem-solving skills
- -

Class flow

At the beginning of each class, topics during the previous class are reviewed. Towards the end of class, students are given exercise problems related to the lecture given that day to solve. To prepare for class, students should read the course schedule section and check what topics will be covered. Required learning should be completed outside of the classroom for preparation and review purposes.

Course schedule/Required learning

  Course schedule Required learning
Class 1 General introduction to biomedical materials (biomaterials) Understand the definition of biomaterials,and roles and categories of biomaterials
Class 2 Preparation of biomedical polymers: Free radical polymerizationadsorption Explain preparation method of bomedical polymers by free radical polymerization
Class 3 Preparation of biomedical polymers: Living polymerization, polycondensation Explain preparation method of bomedical polymers by living polymerization and polycondensation
Class 4 Preparation and biofunctionality of multi-phased materials Understand structures and biomedical properties multi-phased materials
Class 5 Test level of understanding with exercise problems and summary of the first part of the course - Solve exercise problems covering the contents of classes 1–4. Test level of understanding and self-evaluate achievement for classes 1–4.
Class 6 Biocompatiility of materials: Biointerface, Protein adsorption, Cellular response Understand biological responces on materials surfaces
Class 7 Blood compatible polymer materials Explain process of blood coagulation. Understand surface properties required for
Class 8 Biomaterials for drug deliery systems Describe the concept of drug delivery systems. Understand materials and devices for drug delivery systems
Class 9 Surface modification and bioconjugate chemistry Understand the methods for surface modification and bioconjugation to control biological events at biointerface.
Class 10 Test level of understanding with exercise problems and summary of the first part of the course - Solve exercise problems covering the contents of classes 5–9. Test level of understanding and self-evaluate achievement for classes 5–9.
Class 11 Naturally occurring biomaterilas: Structures and properties Explain structures and properties proteinous and polysaccharide biomaterials
Class 12 Naturally occurring biomaterilas: Biomedical applications Explain applications of proteinous biomaterilas and polysaccharide biomaterials
Class 13 Biomaterials for celllular engineering and tissue engineering Understand the concept of cellular therapy and tissue engineering and materials required for these engineering.
Class 14 Biomaterials for diagnoses and biological assays Understand materials and devices for diagnoses and bioasays including bioseparation and bioimaging.
Class 15 Test level of understanding with exercise problems and summary of the first part of the course - Solve exercise problems covering the contents of classes 10–14. Test level of understanding and self-evaluate achievement for classes 10-14.

Textbook(s)

Polymer biomaterials (in Japanese, Corona Co.),

Reference books, course materials, etc.

Biomaterials In Japanese, Corona Co.)
Fundamentals of Biomaterials (Nippon Igaku Kan, in Japanese)

Assessment criteria and methods

Students' knowledge of roles of biomaterials, properties required for biomaterials, preparation and evaluation of biomaterials will be assessed.
Midterm and final exams 80%, exercise problems 20%.

Related courses

  • Biopolymer Engineering
  • Cell Engineering

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Organic Chemistry I-IV, Biochemistry I, II

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