This course will teach you the important role that metal ions play in key biological processes. You will learn that many biological functions are performed at the molecular and the cellular level by metal ions that are incorporated into the metal binding sites of proteins and enzymes. You will begin this course by reviewing the basic principles of inorganic chemistry. Following a brief overview of the spectroscopy methods that scientists use in the study of metals that contain protein, you will understand different of metalloproteins for electron transfer, oxygen activation, selection and uptake of metal, respiratory chain and photoreaction, so on. This course will help you to recognize the importance of inorganic chemistry in various biological systems and understand the principle in biology but also the medical application and the future developments.
By the end of this course, students will be able to:
1. Explain Inorganic Chemistry of Life
2. Explain structures and reaction mechanisms metalloproteins and metalloenzymes
3. Understand and explain function and medicinal application of metal ions in life
Bioinorganic chemistry, metalloprotein, metalloenzyme, biomineral
|Intercultural skills||Communication skills||Specialist skills||Critical thinking skills||Practical and/or problem-solving skills|
（１）At the beginning of each class, the previous class is reviewed, then the essential points of this class are shown as exercise problems.
（２）Towards the end of class, students are given exercise problems related to what is taught on the begining of class to solve as needed.
（３）Before coming to class, students should read the course outcomes and check what topics will be covered. Required learning should be completed outside of the classroom for preparation and review purposes.
|Course schedule||Required learning|
|Class 1||Overview of Bioinorganic chemistry||Understand the discipline of Biological Inorganic Chemistry|
|Class 2||Metal ions in biological system||Understand the outline of metal ions in biological system and importance of metal ions.|
|Class 3||Fundamentals in coordination chemistry I||Fundamentals of inorganic chemistry for understanding Biological Inorganic Chemistry.|
|Class 4||Fundamentals in coordination chemistry II||Fundamentals of inorganic chemistry for understanding Biological Inorganic Chemistry.|
|Class 5||Experimental methdos in biological inorganic chemistry||Outline of experimental techniques used in bioinorganic chemistry|
|Class 6||Electron transfer protein||Structure and function of electron transer proteins|
|Class 7||Oxygen activation by metalloenzymes and oxyen atom tranfer reactions I||Understand the reaction mechanism of oxygen activation in terms of strucutre|
|Class 8||Oxygen activation by metalloenzymes and oxyen atom tranfer reactions II||Understand the reaction mechanism of oxygen activation in terms of strucutre|
|Class 9||Non-heme iron and copper containing oxygenase||Understand the structure and function of non-heme iron and copper containing oxygenases|
|Class 10||Selection and uptake of metal containing units in biology||Explaiin selection and uptake of matal by biolgical system|
|Class 11||Assembly of metal center in biology||Explain the assembly of metal ion center in biology|
|Class 12||Control of the function of metal ion by protein||Understand the role of protein in controlling the function of metal ions|
|Class 13||Respiratory chain and photoreaction center||Overview the electron transfer and energy transduction in respiratory chain and photoreaction center|
|Class 14||Oxidoreductase||Overview the function of oxidoreductase|
|Class 15||Metal ions in medicinal chemistry||Understand the application of metal ions in medicine|
Course materials are provided during class.
Bioinorganic Chemistry （ISBN-10: 4782704836）
Bioinorganic Chemistry （ISBN-10: 4807904574）
The Biological Chemistry of the Elements: The Inorganic Chemistry of Life (ISBN-0198555989)
Students’ course scores are based on midterm (50%) and final(50%) exams