This course will cover structures and functions of biomolecules such as amino acids, proteins, nucleic acids, sugars, lipids, biomembranes, and so on. Topic will include some techniques for studying proteins and nucleic acids, relationship between structures and functions of proteins, regulation of gene expression, and base of genetic engineering. In addition, functions of enzymes, rate of enzymatic reactions, and mechanisms of enzyme catalysis are also explained.
Aims of this course are to learn structures and functions of biomolecules, techniques for studying biomolecules, and mechanisms of their functions for further understanding of life science and biotechnology.
This course is closely related to Biochemistry II, Molecular Biology I, and Molecular Biology II, and it is recommended to enroll all 4 courses.
By the end of this course, students will be able to:
1. Explain chemical and three-dimensional structures of proteins.
2. Explain the relationship between structures and functions of proteins, and techniques for studying proteins.
3. Expalin structures and fucntions of nucleic acids, gene expression, and techniques for studying nucleic acids including genetic engineering.
4. Expalin structures and functions of sugars, polysaccharides, lipids, and biomembranes.
5. Explain structures and functions of enzymes, rates of enzymatic reactions, enzymatic catalysis.
biomolecule, amino acid, protein, nucleic acid, DNA, RNA, gene, genetic engineering, sugar, polysaccharide, lipid, biomembrane, enzyme, reaction rate, reaction mechanism
|Intercultural skills||Communication skills||Specialist skills||Critical thinking skills||Practical and/or problem-solving skills|
When necessary, in the first 10-15 min of each lecture, a summary of the previous lecture is given, followed by the main points of the day's lecture. In the last 10-15 min of each lecture, a quiz may be given to find out if students have learned the material given.
|Course schedule||Required learning|
|Class 1||Amino Acids||Students must be able to explain structures and characters of amino acids.|
|Class 2||Techniques for Protein Study||Students must be able to explain techniques for isolation, purification, and analyses of proteins by chromatographies and electrophoresis.|
|Class 3||Chemical Structure of Proteins||Students must be able to explain the methods for amino acid sequencing of protein, and chemical synthesis of polypeptides.|
|Class 4||Three-Dimensional Structure of Proteins||Students must be able to explain higher-ordered structures of proteins.|
|Class 5||Function of Proteins||Students must be able to explain foldings of proteins, and understand the relationship between structures and fucntions of proteins.|
|Class 6||Nucleic Acids||Students must be able to explain chemical and three-dimensional structures of nucleic acids.|
|Class 7||Gene Expression||Students must be able to explain the gene expression and DNA replication.|
|Class 8||Techniques for Nucleic Acids Study||Students must be able to explain techniques for studying nucleic acids such as DNA sequencing and electrophoresis, and understand base of genetic engineering.|
|Class 9||Sugars and Polysaccharides||Students must be able to explain structures and fucntions of sugars and polysaccharides.|
|Class 10||Lipids||Students must be able to explain structures and functions of lipids and lipid membranes.|
|Class 11||Cell Membranes||Students must be able to explain structures and fucntions of biomembranes.|
|Class 12||Lipoproteins||Students must be able to explain characters of lipoproteins, and the material-transporting mechanism through biomembranes.|
|Class 13||Structure and Function of Enzymes||Students must be able to explain specificities and regualtions of enzymes, and co-enzymes.|
|Class 14||Rates of Enzymatic Reactions||Students must be able to explain rates of enzymatic reactions including Michaelis- Menten equation, and inhibition of enzymatic reactions.|
|Class 15||Enzymatic Catalysis||Students must be able to explain mechanisms of enzymatic catalysis through lysozyme and protease.|
Biochemistry, 4th Edition (Donald Voet, Judith G. Voet, Wiley)
Molecular Biology of the Cell, 5th Edition (Bruce Alberts et al., Garland Science)
Students will be assessed on their ability to describe the biochemical processes given in the course and to utilize the knowledge for problem solving, and students' course scores are based on final examination.