2021 Advanced Biofunctional Chemistry II

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Academic unit or major
Graduate major in Chemical Science and Engineering
Instructor(s)
Tanaka Katsunori 
Course component(s)
Lecture    (ZOOM)
Day/Period(Room No.)
Fri1-2()  
Group
-
Course number
CAP.A426
Credits
1
Academic year
2021
Offered quarter
2Q
Syllabus updated
2021/4/6
Lecture notes updated
-
Language used
English
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Course description and aims

In this lecture, I will explain how the chemistry-based technologies, especially focusing on the synthetic organic chemistry, are applied to understand and regulate the biologically important processes. Especially, in "Advanced Biofunctional Chemistry II", the recent application to drug development, diagnostic and therapeutic fields will be studied.

Student learning outcomes

By taking this lecture, students will understand the following technologies applied to the clinical fields using synthetic organic chemistry.
(1) Labeling and bioconjugation
(2) Molecular imaging
(3) Understanding the in cell functions
(4) Activation of biologically active compounds and drugs

Keywords

Synthetic organic chemistry, molecular imaging, labeling, bioconjugation, in cell functions, biologically active compounds, drugs

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

This lecture proceed in the order of (1) labeling and bioconjugation, (2) molecular imaging, (3) understanding the in cell functions, and (4) activation of biologically active compounds and drugs, as the new synthesis-based technologies for clinical applications. In the last round, exercises and commentary for confirming comprehension degree will be implemented.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Synthetic technology for labeling and bioconjugation Explain the application of labeling and bioconjugation.
Class 2 Synthetic technology for labeling and bioconjugation Explain the application of labeling and bioconjugation.
Class 3 Synthetic technology for molecular imaging Explain the application of molecular imaging.
Class 4 Synthetic technology for understanding the in cell functions Explain the synthetic application for understanding the in cell functions.
Class 5 Synthetic technology for activation of biologically active compounds and drugs Explain the synthetic application for activation of biologically active compounds and drugs.
Class 6 Synthetic technology for activation of biologically active compounds and drugs Explain the synthetic application for activation of biologically active compounds and drugs.
Class 7 Practice problems and interpretation for confirming the level of understanding Solve practice problems by accurate understanding of the above all lectures.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Although the lecture will be delivered on the basis of the following book, the reference materials will be delivered in advance and/or during each lecture.

Tanaka, K. and Vong, K., Handbook of In Vivo Chemistry in Mice: From Lab to Living System (Wiley-VCH) ISBN: 978-3-527-34432-1

Reference books, course materials, etc.

The additional materials will be delivered in advance and/or during each lecture.

Assessment criteria and methods

Practice problems and interpretation for confirming the level of understanding (90%), level of class participation (10%) (The level of class participation will be calculated by discussion, small examination and so on in the lecture).

Related courses

  • CAP.A332 : Advanced Organic Chemistry I (Organic Reactions)
  • CAP.A334 : Advanced Organic Chemistry III (Organic Synthesis)
  • CAP.A425 : Advanced Biofunctional Chemistry I

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Although there are no conditions for taking this course, it is desirable to take advanced biofunctional chemistry I, as well as advanced organic chemistry first and third.

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