In this lecture, I will explain how the chemistry-based technologies, especially focusing on the synthetic organic chemistry, are applied to understand and regulate the biologically important processes. In "Advanced Biofunctional Chemistry I", the basic ideas and chemical technologies in this newly emerging field will be studied.
By taking this lecture, students will understand the following basic ideas and technologies using synthetic organic chemistry.
(1) Labeling and bioconjugation
(2) Molecular imaging
(3) Understanding the in cell functions
(4) Activation of biologically active compounds and drugs
Synthetic organic chemistry, molecular imaging, labeling, bioconjugation, in cell functions, biologically active compounds, drugs
|✔ Specialist skills||Intercultural skills||Communication skills||✔ Critical thinking skills||✔ Practical and/or problem-solving skills|
This lecture proceed in the order of (1) labeling and bioconjugation, (2) molecular imaging, (3) understanding the in cell functions, and (4) activation of biologically active compounds and drugs. In the last round, exercises and commentary for confirming comprehension degree will be implemented.
|Course schedule||Required learning|
|Class 1||Labeling and bioconjugation||Explain the labeling and bioconjugation.|
|Class 2||Labeling and bioconjugation||Explain the labeling and bioconjugation.|
|Class 3||Molecular imaging||Explain the molecular imaging.|
|Class 4||Understanding the in cell functions||Explain the methods for understanding the in cell functions|
|Class 5||Activation of biologically active compounds and drugs||Explain the methods for activation of biologically active compounds and drugs|
|Class 6||Activation of biologically active compounds and drugs||Explain the methods for activation of biologically active compounds and drugs|
|Class 7||Practice problems and interpretation for confirming the level of understanding||Solve practice problems by accurate understanding of the above all lectures.|
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Although the lecture will be delivered on the basis of the following book, the reference materials will be delivered in advance and/or during each lecture.
Tanaka, K. and Vong, K., Handbook of In Vivo Chemistry in Mice: From Lab to Living System (Wiley-VCH) ISBN: 978-3-527-34432-1
The additional materials will be delivered in advance and/or during each lecture.
Practice problems and interpretation for confirming the level of understanding (90%), level of class participation (10%) (The level of class participation will be calculated by discussion, small examination and so on in the lecture).
Although there are no conditions for taking this course, it is desirable to take organic chemistry first to sixth, as well as advanced organic chemistry first and third.