2024 Chemical Science and Engineering Laboratory Ⅲ

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Academic unit or major
Undergraduate major in Chemical Science and Engineering
Tanaka Ken  Ishige Ryohei  Yoshikawa Shiro  Mori Shinsuke  Sekiguchi Hidetoshi  Saito Reiko  Satoh Kotaro  Nakazono Kazuko  Kurniawan Winarto  Kimura Kentaro  Kodama Satoshi  Saito Shogo  Nagashima Yuki  Tanaka Yuya  Kayaki Yoshihito  Kubo Tomohiro  Takahashi Akira  Idota Naokazu 
Class Format
Media-enhanced courses
Day/Period(Room No.)
Mon5-8(大岡山西4号館実験室,大岡山南実験棟4,学術国際情報センター実習室)  Tue5-8(大岡山西4号館実験室,大岡山南実験棟4,学術国際情報センター実習室)  
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Lecture notes updated
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Course description and aims

[Summary of the course] In this course, laboratory experiments on chemical engineering, organic chemistry and polymer chemistry will be instructed for the junior students, who studied Chemical Science and Engineering Laboratories I and II ( or Chemical Engineering and Industrial Chemistry Laboratories I a/b, b/a and II a/b b/a). The following three themes in these fields are set: (1) “Chemical Engineering” consists of two parts. The first one is on design of pipe lines for learning the fluid transportation system based on the mechanical energy balance. The other is on "Heat transfer" for learning the basic treatment on heat transfer by a double-pipe heat exchanger, (2) In the theme of "Organic chemistry", students will learn about typical operating procedures such as preparation and post-treatment of organic synthesis reactions through nucleophilic substitution reactions of carbonyl compounds. (3) In the theme of "Polymer chemistry", students will perform radical polymerization of vinyl monomers and learn the basic concepts of polymer addition polymerization methods, polymerization principles, molecular weight control, and analysis methods.
[Aim of the course] Continuing from Chemical Science and Engineering Laboratory II, in this experiment, students will acquire basic knowledge and experimental research methods of applied chemistry by experiencing experiments related to chemical engineering, organic chemistry, and polymer chemistry, and will learn through the creation of experimental reports. Acquire basic knowledge such as basic concepts and principles of experiments and instrumental analysis and develop practical thinking skills.

Student learning outcomes

The goals of this class are as follows.
(1) Basic experimental operations can be applied according to the experimental purpose of each theme.
(2) Be able to summarize experimental procedures, results, and considerations in the form of a general experimental report.
(3) Be able to explain basic concepts, measurement principles, and their applications related to each theme.
(4) Acquire systematic knowledge about experiments and be able to plan safe and productive chemical experiments.


(Chemical Engineering) Modeling, Simulation, Process Engineering, Process Design, Design of Chemical Reaction System, Design of Separation System, Process Modeling, Process Measurement, Process Control, Gas-Liquid Equilibrium, Theoretical Stages Number, Distillation
(Organic Chemistry) Addition reaction of enolates, carbon-carbon bond formation, conformers, column chromatography, molecular dynamics calculations
(Polymer Chemistry) Radical polymerization, molecular weight measurement, transparency

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

In this experiment, an overview of all experiments will be explained at the beginning. Theme 1: chemical engineering (Pipe design and flow control, heat and flow), theme 2: polymer chemistry (synthesis of acrylic resin by radical polymerization), and theme 3: organic chemistry (organic synthesis and calculation using enolates). (Chemistry) experiments will be carried out in order according to grouping, and in the final session, exercises and explanations will be provided to check understanding.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Heat flow ①: Calculation of heat balance and overall heat transfer coefficient of double pipe heat exchanger The heat balance of a double pipe heat exchanger can be calculated. The overall heat transfer coefficient can be calculated. Learn the structure of heat exchangers.
Class 2 Heat flow ②: Numerical calculation of heat radiation by unsteady heat conduction and convection Learn analysis of conduction heat transfer and convection heat transfer. Learn numerical analysis of heat transfer.
Class 3 Pipe design and flow control ①: Flow rate calculation, pipe design Understand flow rate calculation methods and be able to design pipelines. Analysis using mechanical energy balance is possible.
Class 4 Pipe design and flow control ②: Piping work, manifold production, piping contest Learn piping work and manifold production. Learn how to control flow rate.
Class 5 Utilizing the reactivity of enolates, β-ketoesters are synthesized from ketones. (Unit operation: water prohibition reaction, heating reflux) Learn how to operate the water-restricted reaction.
Class 6 Utilizing the reactivity of enolates, β-ketoesters. are alkylated. (Unit operations: heating under reflux, liquid separation, concentration, TLC) Learn operations related to post-processing of organic reactions such as separation, concentration, and TLC.
Class 7 The product is separated and purified by column chromatography. (Unit operations: column, TLC, concentration) Learn how to operate column chromatography.
Class 8 Consider actual experiments from simulations using computational chemistry. (Unit operation: analysis of spectra used in molecular dynamics calculations, conformational energy analysis, or instrumental analysis) Learn how to operate simulations using computational chemistry.
Class 9 Addition polymerization ①: Radical polymerization of methyl methacrylate Learn principles of radical polymerization and elementary reaction.
Class 10 Addition polymerization ②: Molecular weight measurement by GPC measurement and NMR measurement, determination of chain transfer constant, transparency evaluation of polymethyl methacrylate Learn how to calculate molecular weight using GPC and NMR measurements, how to determine chain transfer constants, and how to evaluate transparency of polymers.
Class 11 Addition polymerization ③: Independent research topic (polymerization) Each group decides on a theme and experiment plan and conducts experiments on polymer synthesis.
Class 12 Addition polymerization ④: Independent research topic (molecular weight measurement and transparency evaluation) Each group determines a theme and experimental plan, and conducts molecular weight measurements and transparency evaluations.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 50 minutes preparing for class and another 50 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.


Textbook for the Chemical Science and Engineering Laboratory III (In Japanese), edited by committee for the chemical science and engineering laboratory (Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering). Students should buy the textbook at Co-op Book Store before the guidance.

Reference books, course materials, etc.

化学同人編集部著 『続 実験を安全に行うために―基本操作・基本測定編―』 第4版(化学同人)ISBN: 978-4-7598-1834-5

Assessment criteria and methods

In principle, full attendance and completion of all experiments are required. Performance will be evaluated based on attitude toward the experiment, including preparation status, experiment report submission status, and scoring results. If you are repeatedly late or submit late, you may be disqualified.

Related courses

  • CAP.G201 : Chemical Engineering Basics
  • CAP.G202 : Chemical Engineering I (Phase & Interface Engineering)
  • CAP.G203 : Chemical Engineering II (Molecular Diffusion)
  • CAP.G205 : Chemical Engineering III (Transport Phenomena Basics)
  • CAP.O201 : Organic Chemistry I(Alkanes, Alkenes, Alkynes)
  • CAP.O202 : Organic Chemistry II(C-X)
  • CAP.O203 : Organic Chemistry III(Benzene・C-O)
  • CAP.O204 : Organic Chemistry IV(C=O・C≡N)
  • CAP.Y201 : Polymer Chemistry Basics
  • CAP.Y203 : Polymer Synthesis II (Chain Polymerizaiton)

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students must have successfully completed both Chemical Science and Engineering Laboratory I (CAP.F205R) and Chemical Science and Engineering Laboratory II (CAP.F206R) or Chemical Engineering and Industrial Chemistry Laboratory I a/b & b/a (CAP.B201.R, CAP.B202.R) and Chemical Engineering and Industrial Chemistry Laboratory II a/b & b/a (CAP.B203.R, CAP.B204.R).

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