[Summary of the course] In this course, nucleophilic additions of aldehydes and ketones, synthesis and reactions of carboxylic acids and nitriles together with acidity, and chemistry of carboxylic acid derivatives based on the properties of carboxylic acids and nucleophilic acyl substitution will be explained.
[Aim of the course] Students learn that many useful compounds can be synthesized by utilizing characters of carbonyl groups. Also students can acquire ability to discuss reaction mechanisms (organic electron theory).
By the end of this course, students acquire the following abilities to:
(1) Explain nucleophilic additions of aldehydes and ketones with showing movement of electrons.
(2) Explain synthesis and reactions of carboxylic acids and nitriles as well as acidity.
(3) Explain synthesis and reactions of carboxylic acid derivatives based on chemistry of carboxylic acids and nucleophilic acyl substitution.
carbonyl groups, aldehydes, ketones, carboxylic acids, nitriles, acyl halides, carboxylic acid anhydrides, esters, amides, nucleophilic addition, nucleophilic acyl substitution
|✔ Specialist skills||Intercultural skills||Communication skills||Critical thinking skills||✔ Practical and/or problem-solving skills|
This course will proceed in the following order: (1) aldehydes and ketones based on nucleophilic additions, (2) carboxylic acids and nitriles together with acidity, (3) carboxylic acid derivatives and nucleophilic acyl substitution. In the last day, practice problems and
interpretation of them will be carried out to confirm the level of understanding.
|Course schedule||Required learning|
|Class 1||Aldehydes and ketones: Nucleophilic addition||Explain nucleophilic addition to aldehydes and ketones.|
|Class 2||Aldehydes and ketones: Protection and deprotection, conjugate addition||Explain protection and deprotection of carbonyl groups, and conjugate addition.|
|Class 3||Carboxylic acid: acidity, Synthesis and reactions||Explain acidity, synthesis and reactions of carboxylic acids.|
|Class 4||Nitriles: Synthesis and reactions||Explain synthesis and reactions of nitriles.|
|Class 5||Carboxylic acid derivatives: Nucleophilic acyl substitution||Explain nucleophilic acyl substitution.|
|Class 6||Chemistry of carboxylic acid derivatives||Explain synthesis and reactions of carboxylic acid derivatives.|
|Class 7||Carboxylic acid derivatives in life, Polymer||Explain reactions of biological carboxylic acid derivatives and synthesis of polymers.|
|Class 8||Practice problems and interpretation for confirming the level of understanding||Solve practice problems by accurate understanding of the above all lectures.|
McMurry Organic Chemistry, international edition of 8 or 9th edition (Cengage Learning)
ISBN 9784807908103(8th Ed), 9784807909131 (9th Ed)
Study Guide with Student Solutions Manual for McMurry's Organic Chemistry, 8 or 9th edition (Cengage Learning) ISBN 9784807909155 (9th Ed), ８9784807908066 (8th Ed)
Practice problems and interpretation for confirming the level of understanding (90%), level of class participation (10%) (The level of class
participation will be calculated by discussion, small examination and so on in the lecture.)
The condition of the study will not be made, but it is desirable to study Organic Chemistry I (Alkanes) (Chemical Science and Engineering),
Organic Chemistry II (Alkenes), Organic Chemistry III (Aromatic Compounds), and Organic Chemistry IV (Nucleophilic Substitution).
tishizon[at]polymer.titech.ac.jp (Takashi Ishizone)
ito.s.ao[at]m.titech.ac.jp (Shigekazu Ito)
Make a reservation by an e-mail in advance.