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2023　Advanced Organic Synthesis

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Academic unit or major
Graduate major in Chemistry
Instructor(s)
Ohmori Ken 
Class Format
Lecture    (Livestream)
Media-enhanced courses
Day/Period(Room No.)
Mon3-4()  Thr3-4()  
Group
-
Course number
CHM.D432
Credits
2
Academic year
2023
Offered quarter
2Q
Syllabus updated
2023/3/20
Lecture notes updated
-
Language used
English
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Course description and aims

In early part of this course, the basic concept of retorsynthesis will be focused, and the latter half part will deal with several examples of multistep synthesis, particularly introducing synthetic approaches to natural products.

Student learning outcomes

At the end of this course, students will be able to have an understanding of basic concept of retrosynthesis and to learn about various synthetic tactics and strategies, enabling access to complex natural products.

Keywords

multistep synthesis
retrosynthesis
natural product synthesis

Competencies that will be developed

✔ Specialist skills Intercultural skills ✔ Communication skills Critical thinking skills ✔ Practical and/or problem-solving skills

Class flow

This course will be conducted online and will include several group discussions and presentations by students.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Basic concept of retrosynthesis Exercise problems might be given in this class.
Class 2 Functional group transformation, addition, and migratory functional group introduction in retrosynthesis Exercise problems might be given in this class.
Class 3 Synthetic strategies for the construction of optically active compounds Exercise problems might be given in this class.
Class 4 Synthetic strategies based on skeletal rearrangements and cascade bond formation Exercise problems might be given in this class.
Class 5 Group discussion and presentation on multi-step synthesis plan for organic compounds, part I Exercise problems might be given in this class.
Class 6 Synthesis of macrolides, part I Exercise problems might be given in this class.
Class 7 Synthesis of macrolides, part II Exercise problems might be given in this class.
Class 8 Synthesis of terpenoids, part I Exercise problems might be given in this class.
Class 9 Synthesis of terpenoids, part II Exercise problems might be given in this class.
Class 10 Group discussion and presentation on multi-step synthesis plan for organic compounds, part II Exercise problems might be given in this class.
Class 11 Synthesis of alkaloids, part I Exercise problems might be given in this class.
Class 12 Synthesis of alkaloids, part II Exercise problems might be given in this class.
Class 13 Synthesis of other classes of natural products Exercise problems might be given in this class.
Class 14 Group discussion and presentation on multi-step synthesis plan for organic compounds, part III Exercise problems might be given in this class.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

DAIGAKUIN-KOUGI II –Organic Chemistry–　(ISBN 9784807908219)

Reference books, course materials, etc.

DAIGAKUIN-KOUGI II –Organic Chemistry– (Exercise problems)

Assessment criteria and methods

Students’ course scores are based on exercise problems and reports.

Related courses

  • CHM.D331 ： Organic Synthesis
  • CHM.D401 ： Basic Concepts of Organic Chemistry
  • CHM.D201 ： Organic Chemistry I
  • CHM.D202 ： Organic Chemistry II
  • CHM.D301 ： Organic Chemistry III

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students require basic knowledge of organic chemistry.

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