2018 Biological engineering

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Academic unit or major
Undergraduate major in Transdisciplinary Science and Engineering
Nakasaki Kiyohiko  Matsumoto Yoshihisa  Nakamura Takashi  Andrews Eden Mariquit 
Course component(s)
Day/Period(Room No.)
Tue5-6(S513)  Fri5-6(S513)  
Course number
Academic year
Offered quarter
Syllabus updated
Lecture notes updated
Language used
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Course description and aims

It is said that interaction between human and microorganisms started around BC5000. At that time, the presence of microorganisms was not recognized, however, fermented foods were empirically produced. Microorganisms were discovered in the 17th century and the role of microorganisms in fermentation was clarified during the 19th century, and following this, various beneficial materials started to be produced. After that, the techniques for animal cell and plant cell cultivation were developed, and together with the rapid progress in the molecular biology, techniques where biological functions could be applied became widespread in the fields of materials production, agriculture, environment and medical care. Students will learn the basics of bioengineering- from cultivation of the organisms to the control and application of their function.

Student learning outcomes

Students will learn the basics of the bioengineering from cultivation of the organisms to the control and application of their function. Firstly, students will understand the characteristics of microbial growth and learn quantitative expression of the pure culture of microorganisms. The cultivation of animal and plant cells has many similar techniques to the cultivation of microorganisms, and this course will clarify the characteristics of cultivating each type of cell. Subsequently, students will understand the methods for the control of the biological function, including genetic manipulation techniques and practical examples of industrial applications of biological functions. Concerning environmental applications, students will acquire the ability to quantitatively express the role of the microbial community, where various microorganisms coexist with complicated interactions in their role in material recycling and conservation of ecosystems.


Microorganisms, Enzymes, Kinetics, Metabolism, Bioreactors, Genetic enginerring, Ecological modeling

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

In the introduction to each class, a summary of the previous lecture is given. After that, the main points of the lecture on that day are discussed in detail. Students are asked to provide solutions to some of the questions that have been posed as necessary. Always check the required learning for each class and be sure to complete them as part of preparation and review.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Cultivation of microorganisms Understand the variety of microorganisms
Class 2 Metabolisms of microorganisms Understand the overview of the metabolisms of microorganisms
Class 3 Microbial growth and conditions Understand microbial growth and cultivation conditions
Class 4 Enzyme kinetics Acquire the skill for numerical expression of enzyme kinetics
Class 5 Microbial kinetics Acquire the skill for numerical expression of microbial growth rate
Class 6 Cultivation methods for microorganisms Explain the types of bioreactor and cultivation methods for microorganisms
Class 7 Immobilized biocatalyst Understand characteristics of the immobilized biocatalyst
Class 8 Cultivation techniques for animal and plant cells Understand cultivation technology for animal and plant cells
Class 9 Genetic engineering techniques Understand an overview of genetic manipulation technology
Class 10 Gene transfer techniques and industrial applications Explain the industrial application of genetic manipulation technology
Class 11 Widely spread biological techniques Understand biotechnology widely used in our life
Class 12 Biorefinary and smart materials Understand smart materials produced by biorefinery and biotechnology
Class 13 Basics of the ecology and material cycle Understand the basics of ecology and material recycling
Class 14 Ecosystem modeling and numerical simulation Explain the method for numerical simulation of the ecosystem
Class 15 From environmental applications and medical supplies to regenerative medicine Explain the wide range of applications from environmental biotechnology to medical care


Text book specified by the instructor.

Reference books, course materials, etc.

Handouts will be distributed at the beginning of class when necessary and elaborated on using PowerPoint slides. PowerPoint documents that are to be used in class will be made available in advance via the OCW system. Students are expected to use these documents for preparation and review purposes.

Assessment criteria and methods

Learning achievement is evaluated by combining results from exercise problems、reports, and final exam.

Related courses

  • GEG.E512 : Utilization of Resources and Wastes for Environment

Prerequisites (i.e., required knowledge, skills, courses, etc.)

None required.

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