Living organisms consist of biomolecules such as proteins and nucleic acids, and complicated biosystems are realized by structural and functional coordination of these biomolecules. To understand biosystems, biophysical characters of biomolecules are important factors. This course will cover the basics of biophysical characters and analysis of biomolecules. Moreover, biophysical characters of artificial proteins and metalloproteins and their applications to medical, cells and bioimaging are explained.
Aims of this course are learning bases and forefront in biophysics, and understanding technological and medical applications of engineered proteins.
By the end of this course, students will be able to:
1. Explain design of artificial proteins and its applications
2. Explain functions of metalloproteins and their applications
3. Understand and explain physical chemistry of proteins
biophysics, artificial proteins, biosensing, control of cellular functions, molecular tool, metalloproteins, imaging, thermodynamics, kinetics
|✔ Specialist skills||✔ Intercultural skills||Communication skills||✔ Critical thinking skills||✔ Practical and/or problem-solving skills|
This course is lectured by five professors. Researches in the field of biophysics are summarized from basic level to advanced level along with current topics.
In order to help understandings of Japanese students, there are cases in which commentaries are added partly in Japanese.
|Course schedule||Required learning|
|Class 1||Research field of biophysics||Students must be able to explain the research field of biophysics and outline of this course.|
|Class 2||Molecular design of high functional artificial proteins||Students must be able to explain the design and construction of genetically engineered artificial proteins with high functions.|
|Class 3||Applications of artificial proteins to biosensing systems||Students must be able to explain the construction and application of genetically engineered proteins for biosensing.|
|Class 4||Regulation of cellular functions by genetically engineered proteins.||Students must be able to explain the design and application of genetically enginerred proteins for regulation of cellular functions.|
|Class 5||Development of molecular tools constructed with genetically engineered proteins.||Students must be able to explain the design of molecular tools consisting of genetically enginerred proteins.|
|Class 6||Application of molecular tools constructed with genetically enginerred proteins.||Students must be able to explain the application of molecluar tools constructed with genetically enginerred proteins.|
|Class 7||Design of artificial metalloproteins||Students must be able to explain the design and functionalization of artificial metalloproteins.|
|Class 8||Model study of metalloproteins||Students must be able to explain the basic design for modeling metalloproteins.|
|Class 9||Inorganic and metal compounds in biotechnology and medical researches||Students must be able to explain the applications of inorganic compounds for cellular and medical researches.|
|Class 10||Oxygen concentration imaging in a single cell||Students must be able to explain the theory of oxygen concentration imaging within a single cell.|
|Class 11||Light energy transduction||Students must be able to explain the theory and application of light energy transduction|
|Class 12||Structure and function of metalloenzymes||Students must be able to explain the structure and function of metalloenzymes.|
|Class 13||Thermodynamics of protein solution||Students must be able to explain behavior of protein molecule in solution base on mixing entropy.|
|Class 14||Thermodynamics of diffusion process||Students must be able to compute the diffusion equation.|
|Class 15||Kinetics of intermolecular interaction between proteins||Students must be able to explain relation of an intermolecula interaction and reaction rate.|
Handouts will be destributed when necessary.
Learning achievement is evaluated by reports.