2018 Science of Metabolism

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Academic unit or major
Graduate major in Life Science and Technology
Hirasawa Takashi  Shiraki Nobuaki  Yamamoto Naoyuki  Kato Akira 
Class Format
Media-enhanced courses
Day/Period(Room No.)
Tue1-2(J221,W831)  Fri1-2(J221,W831)  
Course number
Academic year
Offered quarter
Syllabus updated
Lecture notes updated
Language used
Access Index

Course description and aims

Cellular metabolism is required to obtain the energy for growth and is closely related to cellular responses and diseases. This course will provide an overview of cellular responses and diseases in microorganisms and animals from a viewpoint of metabolism.
The aim of this course is to learn the cellular responses and diseases in organisms and application of their knowledge to the fields of engineering and medical science.

Student learning outcomes

At the end of this course, students will be able to:
1) Understand the metabolic regulations in microbial cells and explain the technologies and examples of bioproduction using microbial cells.
2) Understand the intestinal microflora and impact on host throughout host-microbe communication.
3) Understand the role of the urinary, gastrointestinal, muscular and endocrine systems in mammalian water-electrolyte and energy metabolisms and the mechanisms of related diseases.
4) Understand the metabolic regulations in stem cells and explain cell differentiation technology and therapy utilizing its characteristics.


Microorganisms, Metabolic engineering, Bioproduction, Probiotic bacteria, Commensal bacteria, Symbiotic bacteria, Water-electrolyte metabolism, Energy metabolism, Organ function, Stem cell, Amino acid metabolism, Regenerative medicine

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Students should familiarize themselves with topics described in the required learning section before coming to the class. Students might be given exercise problems related to what is taught on that day to solve.

Course schedule/Required learning

  Course schedule Required learning
Class 1 What is metabolic engineering? Explain the definition of metabolic engineering and methodology of metabolic engineering
Class 2 Metabolic engineering for bioproduction Study the strategies for bioproduction using microbial cells and recent progresses of bioproductions
Class 3 Metabolic flux analysis 1 Understand the methodology for analyzing intracellular metabolic fluxes
Class 4 Metabolic flux analysis 2 Understand the methodology for estimation of metabolic flux ratio using 13C-labeled substrate(s)
Class 5 Microflora analysis Understand the intestinal microflora and the analytical method
Class 6 Host-microbe relationship Understand the impact of intestinal microbe on host
Class 7 Controlling of the intestinal microflora Understand current topics for the controlling of the intestinal microflora
Class 8 Water-electrolyte metabolism in mammals Understand the role of the kidney and intestine in water-electrolyte metabolism at molecular, cellular and tissue level.
Class 9 Regulation of water-electrolyte metabolism and diseases Study the endocrine regulation of water-electrolyte metabolism and related diseases.
Class 10 Energy metabolism in mammals Understand the role of the intestine, liver, adipose tissue and skeletal muscle in energy metabolism at molecular, cellular and tissue level.
Class 11 Regulation of energy metabolism and diseases Study the endocrine regulation of energy metabolism and related diseases.
Class 12 Overview of stem cell metabolism Review the enagy metabolism in embryonic and somatic stem cells
Class 13 Glucose metabolism of stem cells Review the glucose metabolism studied in undergraduate major courses in Life Science and Technology, and understand the glucose metabolism of stem cells
Class 14 Amino acid metabolism of stem cells Understand the amino acid metabolism of stem cells, and its role in the pluripotency and differentiation of stem cells
Class 15 Stem cell metabolism for regenerative medicine Understand the regenerative medicine research using unique metabolic properties of stem cells


None required.

Reference books, course materials, etc.

Course materials are provided through OCW-i.

Assessment criteria and methods

Each instructor will give report assignment related to the lecture. Based on your submitted reports, students will be assessed on their achievements described in "Student learning outcomes."

Related courses

  • 400-level graduate major courses in Life Science and Technology

Prerequisites (i.e., required knowledge, skills, courses, etc.)

No prerequisites are necessary, but it is desirable to have basic knowledge of biochemistry, molecular biology and cell biology.


This course will follow from the basic to advanced levels. For Japanese students, outline of the class will be explained in Japanese at the end of the class.

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