2017 Molecular Developmental Biology and Evolution

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Academic unit or major
Graduate major in Life Science and Technology
Instructor(s)
Kume Shoen  Kawakami Atsushi  Tanaka Mikiko  Kajikawa Masaki  Nikaido Masato 
Course component(s)
Lecture
Mode of instruction
 
Day/Period(Room No.)
Tue3-4(J221,S223)  Fri3-4(J221,S223)  
Group
-
Course number
LST.A406
Credits
2
Academic year
2017
Offered quarter
3Q
Syllabus updated
2017/9/11
Lecture notes updated
-
Language used
English
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Course description and aims

The aim of this class is to understand the advanced subjects of developmental and regenerative biology and evolutionary biology. Students will understand the processes and regulatory mechanisms of animal development and organ formation, and further learn the relationship with applied technologies such as genetic engineering and stem cells. Moreover, students will also learn and understand the evolutionary processes of animal morphologies and genome information.

Student learning outcomes

By the end of this course, students will be able to:
1) Understand the processes and mechanisms of organs derived from the mesoderm.
2) Understand the evolution of developmental processes.
3) Understand the processes and mechanisms of several organs derived from the mesoderm.
4) Understand the molecular background of animal development and principles of genetic engineering.
5) Understand the stem cells and its application to tissue regeneration.
6) Understand the mechanisms of genome evolution.
7) Understand the tissue homeostasis and regeneration.

Keywords

Development, Organ formation, Evolution, Mesoderm, Endoderm, Genetic engineering, Stem cells, Tissue homeostasis, Regeneration

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Active participation of individual students is necessary. When required, students will be given a small test or report as achievement index. These will be used for academic evaluation.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Organ formationⅠ: Development of mesoderm-derived organs 1 - heart, vessels and blood cells (Tanaka, Mikiko) Understand the development of mesoderm-derived organs. Specific instructions will be given in each class.
Class 2 Organ formationⅡ: Development of mesoderm-derived organs 2 - somites and limbs(Tanaka, Mikiko) Understand the development of mesoderm-derived organs.Specific instructions will be given in each class.
Class 3 Organ formation III:Development of ectoderm-derived organs 3 - ectodermal derivatives (Tanaka, Mikiko) Understand the development of mesoderm-derived organs. Specific instructions will be given in each class.
Class 4 Organ formation IV: Developmental processes of endoderm-derived organs 1 (Kume, Shoen) Understand the evolution of developmental processes. Specific instructions will be given in each class.
Class 5 Organ formation V: Developmental processes of endoderm-derived organs 2 (Kume, Shoen) Understand the developmental processes of endoderm-derived organs.Specific instructions will be given in each class.
Class 6 Developmental biology and stem cell biology (Kume, Shoen) Understand the developmental and stem cell biology. Specific instructions will be given in each class.
Class 7 Evolution of sex and recombination  (Kajikawa, Masaki) Understand the evolution of sex and recombination. Specific instructions will be given in each class.
Class 8 Genome evolution of eukaryotes 1  (Kajikawa, Masaki) Understand the genome evolution of eukaryotes. Specific instructions will be given in each class.
Class 9 Genome evolution of eukaryotes 2  (Kajikawa, Masaki) Understand the genome evolution of eukaryotes. Specific instructions will be given in each class.
Class 10 Evolutionary History I: Evolution of Whales and Dolphins (Nikaido) Understand the and evolution of Whales and Dolphins at the DNA level.Specific instructions will be given in each class.
Class 11 Evolutionary History II: Evolution of Coelacanth (Nikaido) Understand the and evolution of coelacanth at the DNA level.Specific instructions will be given in each class.
Class 12 Evolutionary History III: Evolution of Cichlids (Neotropical fish) (Nikaido) Understand the and evolution of east African cichlids at the DNA level.Specific instructions will be given in each class.
Class 13 Tissue homeostasis 101 (Kawakami, Atsushi) Understand the basic concept and examples of tissue homeostasis.Specific instructions will be given in each class.
Class 14 Molecular basis of tissue homeostasis (Kawakami, Atsushi) Understand the molecular background of tissue homeostasis.Specific instructions will be given in each class.
Class 15 Cellular basis of tissue homeostasis (Kawakami, Atsushi) Understand the cellular basis of tissue homeostasis.Specific instructions will be given in each class.

Textbook(s)

None.

Reference books, course materials, etc.

Course materials will be provided during class or through OCW-I as the need arises.

Assessment criteria and methods

Academic assessment will be done by the scores of small test and the performance in the class. When we lecturers think it is necessary, the term-end examination will be conducted.

Related courses

  • LST.A344 : Animal Physiology
  • LST.A335 : Molecular Genetics
  • LST.A346 : Basic Neuroscience
  • LST.A362 : Evolution and Developmental Biology

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Genetics, Evolution and Developmental biology, Animal phisiology, Molecular physiology.

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