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2022　Cell Biology

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Academic unit or major
Undergraduate major in Life Science and Technology
Instructor(s)
Koshikawa Naohiko  Kano Fumi  Fujita Naonobu  Wakabayashi Ken-Ichi 
Class Format
Lecture    (Face-to-face)
Media-enhanced courses
Day/Period(Room No.)
Mon7-8(W331)  Thr7-8(W331)  
Group
-
Course number
LST.A357
Credits
2
Academic year
2022
Offered quarter
1Q
Syllabus updated
2022/3/16
Lecture notes updated
-
Language used
Japanese
Access Index

Course description and aims

The cell is a fundamental unit consists of organisms. There are various organelles in the cell, and the organelles continuously interact with one another by transporting molecules. The cytoskeleton is essentially involved in the transport. Further, various molecules are also transported between the cells across the plasma membrane. Therefore, knowledge of cell biology, such as organelle, cytoskeleton, cell adhesion, and extracellular matrix, is critical for understanding the higher-order biological phenomena, including development.

This course aims to provide a comprehensive overview and insight into the cellular structure, function, and its roles in development.

Student learning outcomes

By the end of this course, students will be able to:
1) Explain the molecular mechanisms of intracellular transport between organelles.
2) Explain the structure and functions of the cytoskeleton.
3) Explain the physiological functions and molecular mechanism of cell-cell and cell-extracellular matrix interaction.
4) Explain the regulatory mechanism of the development of multicellular organisms.

Keywords

Organelle, intracellular transport, cytoskeleton, cell adhesion, extracellular matrix, development

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills ✔ Critical thinking skills Practical and/or problem-solving skills

Class flow

In the first 10 min of each lecture, a summary of the previous lecture is given as necessary, followed by the main points of the day's lecture. In the last 15 min of each lecture, a quiz may be given to find out if students have learned the material given.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Cells and Genomes Students must be able to explain the basics of cells and genomes.
Class 2 Membrane Structure Students must be able to explain the components and the role of the membrane in cells.
Class 3 Membrane Transport of Small Molecules Students must be able to explain the molecular basis of the transfer of biomolecules between membranes.
Class 4 Protein Sorting Students must be able to explain the molecular basis of protein sorting to organelles, especially to mitochondria and endoplasmic reticulum.
Class 5 Membrane Traffic: Exocytosis Students must be able to explain the elementary processes of intracellular membrane traffic and explain the molecular basis of exocytosis.
Class 6 Membrane Traffic: Endocytosis and Autophagy Students must be able to explain the roles and molecular mechanisms of endocytosis and autophagy, which deliver extracellular and intracellular materials to the lysosome, respectively.
Class 7 Analyzing Membrane Traffic Students must be able to explain the techniques to measure the membrane traffic in cells.
Class 8 Cell Adhesion Students must be able to explain the character, mechanism, and biological roles of cell adhesion.
Class 9 Extracellular Matrix (ECM) Students must be able to explain the character, mechanism, and biological roles of ECM.
Class 10 Development of Multicellular Organisms 1 Students must be able to explain the general concept and the regulatory mechanism in the development of multicellular organisms.
Class 11 Development of Multicellular Organisms 2 Students must be able to explain the regulatory mechanism of axis formation and cell differentiation in the development of multicellular organisms.
Class 12 Energy Conversion Students must be able to explain energy conversion mechanisms functioning in mitochondria and chloroplasts.
Class 13 Cytoskeleton and Cell Motility 1 Students must be able to explain the molecular mechanisms of F-actin-related cell motility.
Class 14 Cytoskeleton and Cell Motility 2 Students must be able to explain the molecular mechanisms of microtubule-related cell motility.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Not specified.

Reference books, course materials, etc.

Reference book: Molecular Biology of the Cell (Alberts et al., Garland Science). Handouts will be distributed at the beginning of class when necessary.

Assessment criteria and methods

Based on reports and quiz, whether students achieved the above outcomes is assessed.

Related courses

  • Biochemistry I
  • Molecular Biology I
  • Biochemistry II
  • Molecular Biology II

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students must have completed Biochemistry I, Biochemistry II, Molecular Biology I, and Molecular Biology II or have equivalent knowledge.

Other

Depending on the situation of corona infection, there may be the limited registration and, online transition.

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