Catalysts for reactions occurring in all living organisms are enzymes, so the understanding of the properties and functions of enzymes is indispensable for the understanding of life science and technology. This course covers the basics and applications concerning enzymes. The knowledge of biochemistry and organic chemistry will be applied to understand enzymes. The cutting-edge research using enzymes in the field of the medicinal, food, and environmental sciences, as well as organic chemistry, is also introduced. Furthermore, the opportunities to discuss, communicate and present about the field of studies are given.
The lectures about the enzyme improve your logical thinking ability, communication, and presentation skills as well as help your acquirement of technical knowledge. It is to cultivate the human resources that can lead advanced science and engineering through the studies of enzymes.
By the end of this course, students will be able to:
(1) Acquire the basic knowledge about enzymes and enzyme kinetics. Understand the applied studies of bioengineering related to enzyme.
(2) Acquire the knowledge about enzymes controlling metabolism. Understand the effect of the enzymes on the diseases.
(3) Acquire the knowledge about application of enzymes to organic chemistry.
(4) Understand and present the recent research using enzymes in organic synthesis.
enzyme, enzyme kinetics,
enzymes controlling metabolism,
hydrolase, oxidoreductase, coenzyme
|✔ Specialist skills||Intercultural skills||✔ Communication skills||✔ Critical thinking skills||Practical and/or problem-solving skills|
Classes by Ogura and Ichinose will be lecture-style ones. Classes by Matsuda are interactive, and there are also group discussion opportunity. Presentation may be required at the last class by Matsuda.
|Course schedule||Required learning|
|Class 1||Basics of enzymes (Ogura)||Acquire the knowledge of basics of enzyme through general introduction|
|Class 2||Enzymes used in the laboratory (Ogura)||Acquire the knowledge of enzymes used in the laboratory|
|Class 3||Drug metabolizing enzyme (Ogura)||Acquire the knowledge of drug metabolizing enzyme|
|Class 4||Proteolytic enzymes and homeostasis (Ogura)||Acquire the knowledge of Proteolytic enzymes and homeostasis|
|Class 5||Understanding enzymes with organic chemistry aspect (Matsuda)||Apply the knowledge of organic chemistry to understand enzyme properties and function|
|Class 6||Cancelled (5/6)||Cancelled|
|Class 7||Application of enzymes in the field of organic chemistry (Matsuda)||Understand the applied studies of enzymes in organic chemistry|
|Class 8||Reaction mechanisms of hydrolase (Matsuda)||Understand the mechanism of hydrolase|
|Class 9||Presentation (Matsuda)||Group presentation and discussion|
|Class 10||Reaction mechanisms of oxidoreductase (Matsuda)||Understand the mechanism of oxidoreductase functioning with coenzyme|
|Class 11||Physiological significance of the enzymes and the diseases caused by the dysfunction of the enzyme (Ichinose)||Understand the physiological significance of the enzymes to maintain homeostasis, and the etiology of the diseases caused by the dysfunction of the enzyme|
|Class 12||Individuality caused by genetic variation of the enzymes (Ichinose)||Understand the effects of genetic variations on the individual disposition|
|Class 13||The enzyme as a target for drugs and toxins (Ichinose)||Understand that the many drugs and toxins act on the enzymatic reactions|
|Class 14||Vitamins and minerals in the enzyme reactions, and quiz (Ichinose)||Understand the role of vitamins and minerals in the enzyme reactions Take quiz|
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Students' abilities to understand the basics of enzyme engineering and their abilities to apply the basics to study enzyme and develop enzyme engineering will be assessed.
Class participation, report and quiz 1 during classes by Ogura (31%)
Class participation, presentation and report during classes by Matsuda (38%)
Class participation, report and quiz 2 during classes by Ichinose (31%)