2021 Advanced biological inorganic chemistry

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Academic unit or major
Undergraduate major in Life Science and Technology
Instructor(s)
Kamachi Toshiaki  Ueno Takafumi  Asakura Noriyuki 
Course component(s)
Lecture    (ZOOM)
Day/Period(Room No.)
Tue5-6(H118)  Fri5-6(H118)  
Group
-
Course number
LST.A338
Credits
2
Academic year
2021
Offered quarter
1Q
Syllabus updated
2021/3/19
Lecture notes updated
-
Language used
Japanese
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Course description and aims

This course will teach you the role of metal ions in the biological processes and in the medical applications. You will learn molecular level function and structure in the metal ion related reactions. Following the brief overview, you will understand the role of metal ions in oxidoreductase, atom and group-transfer reaction, electron transfer, and homeostasis of metal ions in biological system.

Student learning outcomes

By the end of this course, students will be able to:
1. Explain structure and function of metal ions in oxidoreductase
2. Explain importance of electron transfer reaction in biological system.
3. Explain medical application of metal ions.
4. Explain homeostasis of metal ions in biological system

Keywords

bioinorganic chemistry, oxidoreductase, electron transfer, metals in medicine, homeostasis of metals

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

(1)At the beginning of each class, the previous class is reviewed, then the essential points of this class are shown as exercise
problems.
(2)Towards the end of class, students are given exercise problems related to what is taught on the begining of class to solve as
needed.
(3)Before coming to class, students should read the course outcomes and check what topics will be covered. Required learning
should be completed outside of the classroom for preparation and review purposes.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Overview of Bioinorganic chemistry, dioxygen binding to metal ions ⽣ Understand the mechanism of dioxygen binding to metal ions
Class 2 Oxidoredutase I: Catalse, monooxygenase Understand the role of metal ions in oxidoreductase
Class 3 Oxidoreductase II: Dioxygenase, superoxide dismutase Understand the role of metal ions in oxidoreductase
Class 4 Oxidoreductase III: Mo containing oxidoreductase Understand the role of metal ions in oxidoreductase
Class 5 Oxidoreductase: etc Understand the role of metal ions in oxidoreductase
Class 6 Group and atom transer Understand the role of metal ions in group or atom transfer
Class 7 Summary and midterm exam of class #1-#6 Test level of understanding of the first part of the course
Class 8 Electron transfer I Understand the reaction mechanism of electron transfer
Class 9 Electron transfer II Understand the reaction mechanism of electron transfer
Class 10 Electron transfer III Understand the reaction mechanism of electron transfer
Class 11 Uptake and storage of metal ions Understand the uptake and storage of metal ions in cell
Class 12 Regulation of metal ions concentration and its application Understand the regulation of metal ions concentration and its application
Class 13 Insertion of metal ions to protein Understand the insertion of metal ions to protein
Class 14 Summary and final exam of class #8-#13 Test level of understanding of the second half of the course

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Basic Bioinorganic Chemistry

Reference books, course materials, etc.

Biophysical Chemistry(ISBN-9784759811407)
Bioinorganic Chemistry (ISBN-10: 4782704836)
Bioinorganic Chemistry (ISBN-10: 4807904574)
The Biological Chemistry of the Elements: The Inorganic Chemistry of Life (ISBN-0198555989)

Assessment criteria and methods

Students' course scores are based on midterm and final exams. Final exam will be held in the class room but according to the COVID-19 conditions, this might be changed.

Related courses

  • LST.A247 : Basic bioinorganic chemistry
  • LST.A201 : Physical Chemistry I

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Understanding of LST.A247: Basic bioinorganic chemistry is required.

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