This course will provide a comprehensive overview of molecular genetics (i.e., how nucleotide sequences of the genomic DNA are transmitted from parents to children). This course will also cover the following topics: methods to study gene functions and genomic nucleotide sequences and the roles of genetics played in elucidating cell functions.
Recently, research and development using gene functions are becoming essential not only in basic life sciences but also in bioengineering, medicine, and agricultural sciences. This course aims at understanding the roles that molecular genetics has played in the elucidation of basic biology and the development of bioengineering, as well as its relationship to our society.
By the end of this course, students will be able to:
1. Explain the basic concept of genetics at molecular levels, as well as that of genomics.
2. Explain the basic molecular mechanisms of genome integrity and the creation of genetic diversity.
3. Explain epigenetics and its basic molecular mechanism.
Mendelian inheritance, Genome, Genomics, Epigenetics, Genome integrity, DNA repair, Genetic diversity
|✔ Specialist skills||Intercultural skills||Communication skills||✔ Critical thinking skills||Practical and/or problem-solving skills|
For the first 10 min of each lecture, a summary of the previous lecture is given as necessary, followed by the main points of the day's lecture. For the last 15 min of each lecture, a quiz may be given to find out if students have learned the material given.
|Course schedule||Required learning|
|Class 1||Mendelian and non-Mendelian inheritance||Students must be able to explain the theory of Menderian and non-Menderian inheritance.|
|Class 2||Chromosome theory of inheritance: gene map and recombination||Students must be able to explain the role of chromosomes in genetic inheritance.|
|Class 3||Forward Genetics: from phenotype to genotype||Students must be able to explain the methodology of the forward genetics and the concept of its "forwardness."|
|Class 4||Genomic diversity.||Students must be able to explain the principles and significance of genomic diversity.|
|Class 5||Overview of modern genomics||Students will be able to understand the history of conceptual and technological progcesses of genomics.|
|Class 6||High-spec DNA sequencers and their applications||Students will be able to grasp pros and cons of all the main DNA sequencing technologies.|
|Class 7||Reverse genetics: from genotype to phenotype||Students will be able to make rough plans of reverse genetic experiments.|
|Class 8||Omics biology||Students will be able to explain the concept and methodologies of comprehensive studies of gene expression.|
|Class 9||Microbial Genetics||Students must be able to explain the basic concept and methodologies of microbial genetics using E. coli and yeast as model organisms.|
|Class 10||Mechanism of genome integrity||Students must be able to explain how cells maintain genome integrity and how an organism creates genetic diversity.|
|Class 11||Sexual reproduction and meiosis||Students must be able to explain the molecular mechanism of meiosis and meiotic recombination.|
|Class 12||Genetics and epigenetics||Students must be able to explain what is epigenetics.|
|Class 13||Mechanism of epigenetics||Students must be able to explain the mechanism of epigenetics.|
|Class 14||Regulation of epigenetics||Students must be able to explain the regulation of epigenetics.|
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Genetics: from Genes to Genomes (Hartwell et al.) (Medical Science International), Molecular Biology of the Cell (Alberts et al.) 5th & 6th ed. (Newton Press), Molecular Cell Biology (Lodish et al.) (W H Freeman & Co.).
Reports, quizzes, etc.
Students must have successfully completed Biochemistry I, Biochemistry II, Molecular Biology I, and Molecular Biology II, or have equivalent knowledge.