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2021　Bioorganic Chemistry

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Academic unit or major
Undergraduate major in Life Science and Technology
Instructor(s)
Seio Kohji  Yuasa Hideya  Mihara Hisakazu  Ohkubo Akihiro 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Mon7-8(W321,W323,W331)  Thr7-8(W241)  
Group
-
Course number
LST.A333
Credits
2
Academic year
2021
Offered quarter
1Q
Syllabus updated
2021/3/19
Lecture notes updated
-
Language used
Japanese
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Course description and aims

This course focuses on the organic chemistry of biomolecules. Topics include organic chemistry of carbohydrates, amino acids, nucleic acids, and conjugate molecules of them. This course is useful for future chemists and biologists.
This course requires no prerequisites, but the students are expected to have preliminary knowledge of basic organic chemistry.

Student learning outcomes

By the end of this course, students will be able to
1) correctly draw chemical structures of carbohydrates, amino acids, nucleic acids　and lipids.
2) find important functional groups in these molecules and understand their chemical reactivity.
3) illustrate the functions of the biomolecules and their conjugates from the view points of organic chemistry.
4) propose the synthetic procedures of the biomolecules.

Keywords

organic chemistry, peptide, nucleic acids , lipids, bioconjugates

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

At the beginning of each class, the previous class is reviewed. Towards the end of class, students are given exercise problems and quizzes related to the lecture given that day to solve.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Introduction: Life and organic chemistry, amino acids Understand concepts and reactions of basic organic chemistry. Draw chemical structures of amino acids and predict their chemical properties.
Class 2 Chemical synthesis of amino acids Draw reaction mechanisms of the synthetic reactions of amino acids and protected amino acids.
Class 3 Chemical synthesis of polypeptides Draw reaction mechanisms of the synthetic reactions of polypeptides
Class 4 Nomenclature and structures of carbohydates Draw chemical structures of carbohydrates and name them according to IUPAC rules
Class 5 Reduction and oxidation of carbohydarates Draw reaction mechanisms of reduction and oxidation reactions of carbohydarates
Class 6 Formation and degradation of glycosidic bonds Draw reaction mechanisms of formation and degradation of glycosidic bonds
Class 7 Exersize (amino acids/peptides, carbohydrates) Answer the problems of organic chemistry of amino acids/peptides, and carbohydrates)
Class 8 Structures and properties of nucleosides and nucleotides Draw chemical structures of nucleotides and predict their chemical properties
Class 9 Reaction of nucleobases Understand nucleophilic and electrophilic reactions of nucleobase., and the reaction mechanisms.
Class 10 Chemical synthesis of oligonucleotides Draw reaction mechanisms of the synthetic reactions of oligonucleotides
Class 11 Structures and properties of lipids Draw chemical structures of lipids and predict their chemical properties
Class 12 Synthesis and properties of lipids(1) Draw reaction mechanisms of the synthetic reactions of lipids
Class 13 Synthesis and properties of lipids(2) Draw reaction mechanisms of the synthetic reactions of lipids
Class 14 Exersize (nucleic acids, lipids) Answer the problems of organic chemistry of nucleic acids, and lipids)

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Organic Chemistry, 6th or 8th Edition
Peter C. Vollhardt, Neil E. Schore

Reference books, course materials, etc.

Study Guide/Solutions Manual for Organic Chemistry
by K. Peter C. Vollhardt and Neil E. Schore

Assessment criteria and methods

Students' knowledge of organic chemistry of the biomolecules, and their ability to apply them to problems will be evaluated by submitting assignments.

Related courses

  • LST.A202 ： Organic Chemistry I (alkanes and haloalkanes)
  • LST.A207 ： Organic Chemistry II (alcohols and alkenes)
  • LST.A212 ： Organic Chemistry III (benzene and ketones)
  • LST.A217 ： Organic Chemistry IV (carbonyl compounds and amines)
  • LST.A343 ： Pharmaceutical Chemistry

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Needing no prerequisite qualifications.

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