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2019　Enzyme Engineering

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Academic unit or major
Undergraduate major in Life Science and Technology
Instructor(s)
Matsuda Tomoko  Ogura Shunichiro  Kamachi Toshiaki  Asakura Noriyuki 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Tue3-4(S011)  Fri3-4(S011)  
Group
-
Course number
LST.A364
Credits
2
Academic year
2019
Offered quarter
1Q
Syllabus updated
2019/3/18
Lecture notes updated
-
Language used
Japanese
Access Index

Course description and aims

Catalysts for reactions occurring in all living organisms are enzymes, so that the understanding of properties and functions of enzymes is indispensable for the understanding of life science and technology. This course covers basics and applications concerning enzymes. The knowledge of inorganic chemistry, physical chemistry, organic chemistry and biochemistry will be applied to the understand enzymes. The cutting-edge research using enzymes in the field of inorganic, physical, and organic chemistry as well as the medicinal, food, and environmental sciences is also introduced. Furthermore, the opportunities to discuss, communicate and present about the field of studies are given.

The lectures about the enzyme improve your logical thinking ability, communication and presentation skills as well as help your acquirement of the technical knowledge. It is to cultivate the human resources who can lead advanced science and engineering through the studies of enzymes.

Student learning outcomes

By the end of this course, students will be able to:
(1)　Apply the knowledge of inorganic chemistry to understand enzyme science and technology and foster the abilities to apply the acquired knowledge of enzyme to back to inorganic chemistry.
(2)　Apply the knowledge of physical chemistry to understand enzyme science and technology and foster the abilities to apply　the acquired knowledge of enzyme to back to physical chemistry.
(3)　Apply the knowledge of organic chemistry to understand enzyme science and technology and foster the abilities to apply the acquired knowledge of enzyme to back to organic chemistry.
(4)　Acquire the knowledge of enzymes in the field of medicinal, food, and environmental sciences and foster the abilities to apply the acquired knowledge of enzyme to back to the field of medicinal, food, and environmental sciences.
(5)　Understand the applied research about enzymes and present the search of recent studies about enzymes.

Keywords

enzyme, metalloenzyme, electron transfer in enzyme, hydrolase, oxidoreductase, coenzyme, enzyme useful in medical field, enzyme for food processing, enzyme for environmental clarification

Competencies that will be developed

✔ Specialist skills Intercultural skills ✔ Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Generally, lectures are given. It can be interactive classes. Presentation about application study of enzymes may be required during class 6 to class 10.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Basics of understanding enzymes in the viewpoint of inorganic chemistry (Kamachi) Apply the knowledge of inorganic chemistry to understand metalloenzyme properties and function
Class 2 Application of enzymes in the field of inorganic chemistry (Kamachi) Understand the applied studies of metalloenzyme
Class 3 Basics of understanding enzymes in the viewpoint of physical chemistry (Kamachi) Apply the knowledge of physical chemistry to understand electron transfer in enzymes
Class 4 Application of enzymes in the field of physical chemistry (Asakura) Understand the applied studies of enzyme involving electron transfer
Class 5 Review of class 1 through class 4 and quiz 1 (Asakura) Review properties and function of metalloenzyme and enzyme involving electron transfer
Class 6 Basics of understanding enzymes in the view point of organic chemistry (Matsuda) Apply the knowledge of organic chemistry　to understand enzyme properties and function
Class 7 Application of enzymes in the field of organic chemistry (Matsuda) Understand the applied studies of enzyme with organic chemistry view points
Class 8 Reaction mechanisms of hydrolase (Matsuda) Understand the mechanism of hydrolase
Class 9 Reaction mechanisms of oxidoreductase (Matsuda) Understand the mechanism of oxidoreductase functioning with coenzyme
Class 10 Review of class 6 through class 9 and quiz 2(Matsuda) Review properties and function of enzyme with organic chemistry view points
Class 11 Basics of enzymes in medicinal science (Ogura) Acquire the knowledge of basics of enzymes in medicinal science
Class 12 Application of enzymes in medicinal science (Ogura) Acquire the knowledge of application of enzymes in medicinal science
Class 13 Basics and application of enzymes in food science (Ogura) Acquire the knowledge of basics and application of enzymes in food science
Class 14 Basics and application of enzymes in environmental science (Ogura) Acquire the knowledge of basics and application of enzymes in environmental science
Class 15 Review of class 10 through class 14 and quiz 3 (Ogura) Review properties and function of enzyme in the field of medicinal, food, and environmental sciences

Textbook(s)

For class 1 5 and 11-15, handout is given.

Reference books, course materials, etc.

For class 6〜10: The Organic Chemistry Of Biological Pathways (John E. McMurry, Tadhg P. Begley) Roberts & Co

Assessment criteria and methods

Students' abilities to understand the basics of enzyme engineering and their abilities to apply the basics to study enzyme and develop enzyme engineering will be assessed.
Class participation toward class 1〜5 and quiz 1 (34%)
Class participation toward class 6〜10 and quiz 2 (33%)
Class participation toward class 11〜15 and quiz 3 (33%)

Related courses

  • Organic chemistry I〜 IV
  • Phisical chemistry I〜 III
  • Biochemistry I, II

Prerequisites (i.e., required knowledge, skills, courses, etc.)

None

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