This course will provide a comprehensive overview of molecular genetics (i.e., how nucleotide sequences of the genomic DNA are transmitted from parents to children). This course will also cover the following topics: methods to study gene functions and genomic nucleotide sequences and the roles of genetics played in elucidating cell functions.
Recently, research and development using gene functions are becoming essential not only in basic life sciences but also in bioengineering, medicine, and agricultural sciences. This course aims at understanding the roles that molecular genetics has played in the elucidation of basic biology and the development of bioengineering, as well as its relationship to our society.
By the end of this course, students will be able to:
1. Explain the basic concept of genetics at molecular levels, as well as that of classical and modern genomics.
2. Explain the molecular basis of eukaryotic and prokaryotic cell motility, as well as how genetics contributed to this field.
3. Explain the molecular basis of the cell cycle in yeasts and higher eukaryotes, as well as how genetics contributed to this field.
Menderian inheritance, Genome, Cell motility, Cell cycle
|Intercultural skills||Communication skills||Specialist skills||Critical thinking skills||Practical and/or problem-solving skills|
For the first 10 min of each lecture, a summary of the previous lecture is given as necessary, followed by the main points of the day's lecture. For the last 15 min of each lecture, a quiz may be given to find out if students have learned the material given.
|Course schedule||Required learning|
|Class 1||Mendelian and non-Mendelian inheritance||Students must be able to explain the theory of Menderian and non-Menderian inheritance.|
|Class 2||Chromosome theory of inheritance: gene map and recombination||Students must be able to explain the role of chromosomes in genetic inheritance.|
|Class 3||Forward Genetics: from phenotype to genotype||Students must be able to explain the methodology of the forward genetics and the concept of its "forwardness."|
|Class 4||Transposable elements and host genomic diversity.||Students must be able to explain the impact of transposable elements on the host genome diversity.|
|Class 5||Overview of modern genomics||Students will be able to understand the history of conceptual and technological progcesses of genomics.|
|Class 6||High-spec DNA sequencers and their applications||Students will be able to grasp pros and cons of all the main DNA sequencing technologies.|
|Class 7||Reverse genetics: from genotype to phenotype||Students will be able to make rough plans of reverse genetic experiments.|
|Class 8||Systems biology||Students will be able to explain the concept and methologies to study any biological networks.|
|Class 9||F-actin-related cell motility||Students must be able to explain the molecular mechanisms of F-actin-related cell motility.|
|Class 10||Microtubule-related cell motility||Students must be able to explain the molecular mechanisms of microtubule-related cell motility.|
|Class 11||Intermediate filaments and classical genetics||Students must be able to explain the importance of intermediate filaments and classical genetics to study cell motility.|
|Class 12||Molecular genetics of the cell cycle in yests||Students must be able to explain the basis of yeast molecular genetics.|
|Class 13||Molecular genetics of the cell cycle in higher eukaryotes||Students must be able to explain the basis of yeast molecular genetics.|
|Class 14||Cell cycle controls in many eukaryotic cells||Students must be able to explain the general and comprative cell cycle control.|
|Class 15||Genetic control of circadian rhythms||Students must be able to explain the concepts of circadian rhythm as well as the pathogenesis of biological clock.|
Genetics: from Genes to Genomes (Hartwell et al.) (Medical Science International), Molecular Biology of the Cell (Alberts et al.) (Newton Press), Molecular Cell Biology (Lodish et al.) (W H Freeman & Co.). Handouts will be distributed at the beginning of class when necessary.
Final exam: 100%
Students must have successfully completed Biochemistry I, Biochemistry II, Molecular Biology I, and Molecular Biology II, or have equivalent knowledge.