Chemical structure and a basic concept about the biochemical significance of the nucleic acid, protein, and polysaccharide as biopolymers, are reviewed. After having done the statement about the general property of biopolymers, the structure and the function of various biopolymers concerned with those biosynthesis processes are understood, and the advanced theory and method to the regulations of the reaction mechanism and the utilization in the field of biotechnology are lectured.
First, students will aim to learn about nomenclature, the molecular structure of the biopolymer compound, and the higher order structure.
Then, students will gain an understanding of the biochemical significance including the in vivo role of nucleic acids, proteins, and the carbohydrate chains.
Finally, students will understand how to use each biopolymer for biotechnology.
By the end of this course, students will be able to:
1. Understand the chemical structure and physical property of nucleic acids, proteins, and polysaccharides as polymer compounds.
2. Understand the biological significance of biopolymer through the study of biosynthesis.
3. Understand the biopolymer for constructing novel biomaterials.
nucleic acids, protein, polysacchride, molecular weight, biosynthesis, chemical structure and the phsical property, biomaterial
|Intercultural skills||Communication skills||Specialist skills||Critical thinking skills||Practical and/or problem-solving skills|
Lectures are to be given in order according to the textbook. Students are given concise exercise problems in each class, and their solutions and remarks will be explained at the beginning of the next class.
|Course schedule||Required learning|
|Class 1||Concept of polymer compounds||Understand and illustrate polymer compounds|
|Class 2||Molecular weight and its distribution of polymers||Understand and illustrate molecular weight and its distribution of polymer compounds|
|Class 3||Relationship between structures and properties of polymers||Understand and illustrate physical property and functionality of polymer compounds|
|Class 4||Biosynthesis of nucleic acids||Understand and illustrate biosynthesis of nucleic aicds|
|Class 5||Chemical structures and properties of nucleic acids||Draw nucleotides' structures and illustrate nucleic acid structures|
|Class 6||Reatcitivy of nucleic acids||Illustrate chemical reacitity of nucleobase, ribose and phosphate parts.|
|Class 7||From nucleic acid chemistry to nucleic acid technology||Illustrate the applications of artificial nucleic acids in life science and technology|
|Class 8||Biosynthesis of proteins||Understand and illustrate biosynthesis of proteins|
|Class 9||Chemical structures and properties of proteins||Draw amino acids' structures and illustrate protein structures|
|Class 10||Reatcitivy of proteins||Illustrate chemical reacitity of amino acid side chains.in proteins.|
|Class 11||From protein chemistry to protein technology||Illustrate the applications of artificial proteins in life science and technology|
|Class 12||Biosynthesis of polysacchride||Understand and illustrate biosynthesis of polysacchride|
|Class 13||Chemical structures and properties of polysacchride||Draw monosacchrides' structures and illustrate polysacchride structures|
|Class 14||Reatcitivy of polysacchride||Illustrate chemical reacitity of monosacchrides|
|Class 15||From polysacchride chemistry to polysacchride technology||Illustrate the applications of artificial polysacchrides in life science and technology|
Organic Chemistry - Structure and Function, 6th ed., K. P. C. Vollhardt and N, E. Schore, W. H. Freeman and Co., New York, 2011; The Japanese translation, 6th ed., Kagakudojin, Kyoto, 2011. (Japanese) and Biochemistry, 6th ed., K. P. C. Vollhardt and D. Voet, J. G. Voet and Co., 2011; The Japanese translation,3rd ed., Tokyo Kagakudojin, Tokyo, 2005. (Japanese)
Assessment on the concise plroblem in each classs (20%) and the final exam (80%)
Toshiaki Mori （tmori[at]bio.titech.ac.jp, 045-924-5782) Koji Seio（kseio[at]bio.titech.ac.jp, 045-924-5136) Takafumi Ueno(tueno[at]bio.titech.ac.jp, 045-924-5844) Atsushi Maruyama (amaruyama[at]bio.titech.ac.jp, 045-924-5840)
requirement for appointment to lecturer