This course focuses on the organic chemistry of biomolecules. Topics include organic chemistry of carbohydrates, amino acids, nucleic acids, and conjugate molecules of them. This course is useful for future chemists and biologists.
This course requires no prerequisites, but the students are expected to have preliminary knowledge of basic organic chemistry.
By the end of this course, students will be able to
1) correctly draw chemical structures of carbohydrates, amino acids, nucleic acids and lipids.
2) find important functional groups in these molecules and understand their chemical reactivity.
3) illustrate the functions of the biomolecules and their conjugates from the view points of organic chemistry.
4) propose the synthetic procedures of the biomolecules.
organic chemistry, peptide, nucleic acids , lipids, bioconjugates
|Intercultural skills||Communication skills||Specialist skills||Critical thinking skills||Practical and/or problem-solving skills|
At the beginning of each class, the previous class is reviewed. Towards the end of class, students are given exercise problems and quizzes related to the lecture given that day to solve.
|Course schedule||Required learning|
|Class 1||Introduction: Life and organic chemistry, amino acids||Understand concepts and reactions of basic organic chemistry. Draw chemical structures of amino acids and predict their chemical properties.|
|Class 2||Chemical synthesis of amino acids||Draw reaction mechanisms of the synthetic reactions of amino acids and protected amino acids.|
|Class 3||Chemical synthesis of polypeptides||Draw reaction mechanisms of the synthetic reactions of polypeptides|
|Class 4||Nomenclature and structures of carbohydates||Draw chemical structures of carbohydrates and name them according to IUPAC rules|
|Class 5||Reduction and oxidation of carbohydarates||Draw reaction mechanisms of reduction and oxidation reactions of carbohydarates|
|Class 6||Formation and degradation of glycosidic bonds||Draw reaction mechanisms of formation and degradation of glycosidic bonds|
|Class 7||Exercise （amino acid/peptide/carbohydrate）||Thoroughly understand the contents of class 9-14 by solving the exersize problems|
|Class 8||Midterm examination & exersice（carbohydrates・peptides）||Check the comprehension for class 1 to 6 for perfect understanding of the contents|
|Class 9||Structures and properties of nucleosides and nucleotides||Draw chemical structures of nucleotides and predict their chemical properties|
|Class 10||Structures and properties of oligonucleotides||Illustrate the structural properties of oligonucleotides|
|Class 11||Chemical synthesis of oligonucleotides||Draw reaction mechanisms of the synthetic reactions of oligonucleotides|
|Class 12||Structures and properties of lipids||Draw chemical structures of lipids and predict their chemical properties|
|Class 13||Synthesis and properties of lipids||Draw reaction mechanisms of the synthetic reactions of lipids|
|Class 14||Chemistry of bioconjugate molecules||Illustrate the structural properties of bioconjugates molecules|
|Class 15||Exersice （nucleic acids/lipids/bioconjugate molecules）||Thoroughly understand the contents of class 9-14 by solving the exersize problems|
Organic Chemistry, 6th Edition
Peter C. Vollhardt, Neil E. Schore
Study Guide/Solutions Manual for Organic Chemistry
by K. Peter C. Vollhardt and Neil E. Schore
Students' knowledge of organic chemistry of the biomolecules, and their ability to apply them to problems will be assessed.
Midterm and final exams70%, quizzes in each class 30%.
Needing no prerequisite qualifications.