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2017　Biological Inorganic Chemistry

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Academic unit or major
Undergraduate major in Life Science and Technology
Instructor(s)
Ueno Takafumi  Kamachi Toshiaki 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Tue1-2(H101)  Fri1-2(H101)  
Group
-
Course number
LST.A247
Credits
2
Academic year
2017
Offered quarter
4Q
Syllabus updated
2017/10/4
Lecture notes updated
-
Language used
Japanese
Access Index

Course description and aims

This course will teach you the important role that metal ions play in key biological processes. You will learn that many biological functions are performed at the molecular and the cellular level by metal ions that are incorporated into the metal binding sites of proteins and enzymes. You will begin this course by reviewing the basic principles of inorganic chemistry. Following a brief overview of the spectroscopy methods that scientists use in the study of metals that contain protein, you will understand different of metalloproteins for electron transfer, oxygen activation, selection and uptake of metal, respiratory chain and photoreaction, so on. This course will help you to recognize the importance of inorganic chemistry in various biological systems and understand the principle in biology but also the medical application and the future developments.

Student learning outcomes

By the end of this course, students will be able to:
1. Explain Inorganic Chemistry of Life
2. Explain structures and reaction mechanisms metalloproteins and metalloenzymes
3. Understand and explain function and medicinal application of metal ions in life

Keywords

Bioinorganic chemistry, metalloprotein, metalloenzyme, biomineral

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills ✔ Practical and/or problem-solving skills

Class flow

（１）At the beginning of each class, the previous class is reviewed, then the essential points of this class are shown as exercise problems.
（２）Towards the end of class, students are given exercise problems related to what is taught on the begining of class to solve as needed.
（３）Before coming to class, students should read the course outcomes and check what topics will be covered. Required learning should be completed outside of the classroom for preparation and review purposes.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Overview of Bioinorganic chemistry Understand the discipline of Biological Inorganic Chemistry
Class 2 Metal ions in biological system Understand the outline of metal ions in biological system and importance of metal ions.
Class 3 Fundamentals in coordination chemistry I Fundamentals of inorganic chemistry for understanding Biological Inorganic Chemistry.
Class 4 Fundamentals in coordination chemistry II Fundamentals of inorganic chemistry for understanding Biological Inorganic Chemistry.
Class 5 Experimental methdos in biological inorganic chemistry Outline of experimental techniques used in bioinorganic chemistry
Class 6 Electron transfer protein Structure and function of electron transer proteins
Class 7 Oxygen activation by metalloenzymes and oxyen atom tranfer reactions I Understand the reaction mechanism of oxygen activation in terms of strucutre
Class 8 Oxygen activation by metalloenzymes and oxyen atom tranfer reactions II Understand the reaction mechanism of oxygen activation in terms of strucutre
Class 9 Non-heme iron and copper containing oxygenase Understand the structure and function of non-heme iron and copper containing oxygenases
Class 10 Selection and uptake of metal containing units in biology Explaiin selection and uptake of matal by biolgical system
Class 11 Assembly of metal center in biology Explain the assembly of metal ion center in biology
Class 12 Control of the function of metal ion by protein Understand the role of protein in controlling the function of metal ions
Class 13 Respiratory chain and photoreaction center Overview the electron transfer and energy transduction in respiratory chain and photoreaction center
Class 14 Oxidoreductase Overview the function of oxidoreductase
Class 15 Metal ions in medicinal chemistry Understand the application of metal ions in medicine

Textbook(s)

Course materials are provided during class.

Reference books, course materials, etc.

Biophysical Chemistry（ISBN-9784759811407）
Bioinorganic Chemistry （ISBN-10: 4782704836）
Bioinorganic Chemistry （ISBN-10: 4807904574）
The Biological Chemistry of the Elements: The Inorganic Chemistry of Life　(ISBN-0198555989)

Assessment criteria and methods

Students’ course scores are based on midterm (50%) and final(50%) exams

Related courses

  • LST.A201 ： Physical Chemistry I
  • CAP.A373 ： Inorganic Chemistry (Coordination Chemistry)

Prerequisites (i.e., required knowledge, skills, courses, etc.)

No prerequisites.

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