This course focuses on the materials used in biomedical fields. Topics include the general introduction of biomedical materials (biomaterials), biomaterials from natural sources, design and preparation of biomedical polymers, surface modification of materials and bioconjugate materials composed of biomolecules and artificially synthetic materials. By combining lectures and exercises, the course enables students to understand and acquire the fundamentals of biomaterials widely applicable to biomedical uses.
Biomaterials that are used in contact with biological components is crucially important for artificial organs, drug delivery and tissue engineering devices and diagnostic tools. Understanding of biological events occurred at interface between material surface and biological components is crucial to design biomaterials with high functionality, safety and reliability. Biomaterials design also require knowledge of material preparation, modification and characterization methods. Surface modification chemistry and bioconjugate chemistry are also important for biomaterials design. Students will learn fundamentals of biomaterials science that is necessary for biomaterial design.
By the end of this course, students will be able to:
1) Explain the definition of biomaterials, and the roles and categories of biomaterials.
2) Explain bio-responses at material surfaces and propose ideas to design biomaterials.
3) Explain protein and polysaccharide biomaterials and their properties and functions.
4) Explain polymer biomaterials and their preparation methods, properties and functions.
5) Explain the concept of surface modification and bioconjugation and its application to biomaterials.
Bio-interface, Naturally occurring biomaterials, Biocompatibility, Blood compatibility, Drug delivery systems, Tissue engineering, Hydrogels,
|✔ Specialist skills||Intercultural skills||Communication skills||✔ Critical thinking skills||✔ Practical and/or problem-solving skills|
At the beginning of each class, topics during the previous class are reviewed. Towards the end of class, students are given exercise problems related to the lecture given that day to solve. To prepare for class, students should read the course schedule section and check what topics will be covered. Required learning should be completed outside of the classroom for preparation and review purposes.
|Course schedule||Required learning|
|Class 1||General introduction to biomedical materials (biomaterials)||Understand the ｄefinition of biomaterials,and roles and categories of biomaterials|
|Class 2||Biocompatiility of materials: Biointerface, Protein adsorption, Cellular responses||Understand biological responces on materials surfaces|
|Class 3||Naturally occurring biomaterilas: Structures and properties||Explain structures and properties proteinous and polysaccharide biomaterials|
|Class 4||Naturally occurring biomaterilas: Biomedical applications||Explain applications of proteinous biomaterilas and polysaccharide biomaterials|
|Class 5||Test level of understanding with exercise problems and summary of the first part of the course - Solve exercise problems covering the contents of classes 1–4.||Test level of understanding and self-evaluate achievement for classes 1–4.|
|Class 6||Preparation of biomedical polymers: Free radical polymerization||Explain preparation method of bomedical polymers by free radical polymerization|
|Class 7||Preparation of biomedical polymers: Living polymerization and polycondensation||Explain preparation method of bomedical polymers by living polymerization and polycondensation|
|Class 8||Biofunctionality of multi-phased materials||Understand structures and biomedical properties multi-phased materials|
|Class 9||Blood compatible polymer materials||Explain process of blood coagulation. Understand surface properties required for blood compatibility|
|Class 10||Test level of understanding with exercise problems and summary of the first part of the course - Solve exercise problems covering the contents of classes 5–9.||Test level of understanding and self-evaluate achievement for classes 5–9.|
|Class 11||Biomaterials for drug deliery systems||Describe the concept of drug delivery systems. Understand materials and devices for drug delivery systems|
|Class 12||Biomaterials for celllular engineering and tissue engineering||Understand the concept of cellular therapy and tissue engineering and materials required for these engineering.|
|Class 13||Surface modification and bioconjugate chemistry||Understand the methods for surface modification and bioconjugation to control biological events at biointerface.|
|Class 14||Biomaterials for diagnoses and biological assays||Understand materials and devices for diagnoses and bioasays including bioseparation and bioimaging.|
|Class 15||Test level of understanding with exercise problems and summary of the first part of the course - Solve exercise problems covering the contents of classes 10–14.||Test level of understanding and self-evaluate achievement for classes 10-14.|
Polymer biomaterials (in Japanese, Corona Co.), Biomaterials In Japanese, Corona Co.)
Fundamentals of Biomaterials (Nippon Igaku Kan, in Japanese)
Students' knowledge of roles of biomaterials, properties required for biomaterials, preparation and evaluation of biomaterials will be assessed.
Midterm and final exams 80%, exercise problems 20%.
Organic Chemistry I-IV, Biochemistry I, II