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- 工学院，物質理工学院，環境・社会理工学院共通科目
- Liberal arts and basic science courses
- First-Year Courses
- School of Science
- School of Engineering
- School of Materials and Chemical Technology
- School of Computing
- School of Life Science and Technology
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School of Environment and Society
- Department of Architecture and Building Engineering
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- Graduate major in Technology and Innovation Management
- Common courses
- Liberal arts and basic science courses
- Academic unit or major
- Graduate major in Chemical Science and Engineering
- Instructor(s)
- Tanaka Katsunori
- Class Format
- Lecture
- Media-enhanced courses
- Day/Period(Room No.)
- Fri1-2(Zoom)
- Group
- -
- Course number
- CAP.A425
- Credits
- 1
- Academic year
- 2020
- Offered quarter
- 4Q
- Syllabus updated
- 2020/11/30
- Lecture notes updated
- -
- Language used
- English
- Access Index
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Course description and aims
In this lecture, I will explain how the chemistry-based technologies, especially focusing on the synthetic organic chemistry, are applied to understand and regulate the biologically important processes. In "Advanced Biofunctional Chemistry I", the basic ideas and chemical technologies in this newly emerging field will be studied.
Student learning outcomes
By taking this lecture, students will understand the following basic ideas and technologies using synthetic organic chemistry.
(1) Labeling and bioconjugation
(2) Molecular imaging
(3) Understanding the in cell functions
(4) Activation of biologically active compounds and drugs
Keywords
Synthetic organic chemistry, molecular imaging, labeling, bioconjugation, in cell functions, biologically active compounds, drugs
Competencies that will be developed
| ✔ Specialist skills | Intercultural skills | Communication skills | ✔ Critical thinking skills | ✔ Practical and/or problem-solving skills |
Class flow
This lecture proceed in the order of (1) labeling and bioconjugation, (2) molecular imaging, (3) understanding the in cell functions, and (4) activation of biologically active compounds and drugs. In the last round, exercises and commentary for confirming comprehension degree will be implemented.
Course schedule/Required learning
| Course schedule | Required learning | |
|---|---|---|
| Class 1 | Labeling and bioconjugation | Explain the labeling and bioconjugation. |
| Class 2 | Labeling and bioconjugation | Explain the labeling and bioconjugation. |
| Class 3 | Molecular imaging | Explain the molecular imaging. |
| Class 4 | Understanding the in cell functions | Explain the methods for understanding the in cell functions |
| Class 5 | Activation of biologically active compounds and drugs | Explain the methods for activation of biologically active compounds and drugs |
| Class 6 | Activation of biologically active compounds and drugs | Explain the methods for activation of biologically active compounds and drugs |
| Class 7 | Practice problems and interpretation for confirming the level of understanding | Solve practice problems by accurate understanding of the above all lectures. |
Out-of-Class Study Time (Preparation and Review)
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Textbook(s)
Although the lecture will be delivered on the basis of the following book, the reference materials will be delivered in advance and/or during each lecture.
Tanaka, K. and Vong, K., Handbook of In Vivo Chemistry in Mice: From Lab to Living System (Wiley-VCH) ISBN: 978-3-527-34432-1
Reference books, course materials, etc.
The additional materials will be delivered in advance and/or during each lecture.
Assessment criteria and methods
Practice problems and interpretation for confirming the level of understanding (90%), level of class participation (10%) (The level of class participation will be calculated by discussion, small examination and so on in the lecture).
Related courses
- CAP.B214 ： Organic Chemistry IV (Nucleophilic Substitution)
- CAP.B315 ： Organic Chemistry V (Carbonyl Compounds)
- CAP.B316 ： Organic Chemistry VI (Amines)
- CAP.A332 ： Advanced Organic Chemistry Ⅰ (Organic Reactions)
- CAP.A334 ： Advanced Organic Chemistry III (Organic Synthesis)
Prerequisites (i.e., required knowledge, skills, courses, etc.)
Although there are no conditions for taking this course, it is desirable to take organic chemistry first to sixth, as well as advanced organic chemistry first and third.
