[Summary of the lecture] In this lecture, "reactions via allyl metal complexes (isomerization and allylic substitution reactions)", "reactions via carbene complexes (cyclopropanation and metathesis reactions)", "reactions via metallacycles (cycloaddition and cycloisomerization reactions)", and "reactions via electrophilic activation of unsaturated bonds (functionalization reactions of alkenes and alkynes)", which are particularly important for the application to organic synthesis in the organometallic catalyst chemistry, will be explained.
[Aim of the lecture] The organometallic catalysis chemistry is extremely important in not only laboratory organic synthesis but also industrial organic synthesis. In this lecture, various catalyses are classified and explained by the reaction mechanism. In addition, the development of asymmetric variants and application of these catalyses to the industrial synthesis of organic fine chemicals will also be introduced. Finally, students acquire the ability to apply organometallic catalysis to organic synthesis.
By the end of this course, students acquire the following ability:
(1) Ability to explain "reactions via allyl metal complexes ".
(2) Ability to explain "reactions via carbene complexes".
(3) Ability to explain "reactions via metallacycles".
(4) Ability to explain "reactions via electrophilic activation of unsaturated bonds".
(5) Ability to apply organometallic catalysis (1)-(4) to organic synthesis.
Reactions via allyl metal complexes, allylic substitution reactions, isomerization reactions, reactions via carbene complexes, cyclopropanation reactions, metathesis reactions, reactions via metallacycles, cycloaddition reactions, cycloisomerization reactions, reactions via electrophilic activation of unsaturated bonds, functionalization reactions of alkenes, functionalization reactions of alkynes
|Intercultural skills||Communication skills||Specialist skills||Critical thinking skills||Practical and/or problem-solving skills|
This lecture will proceed in the following order: "reactions via allyl metal complexes", "reactions via carbene complexes", "reactions via metallacycles", and "reactions via electrophilic activation of unsaturated bonds". In addition, the development of asymmetric variants and application of these catalyses to the industrial synthesis of organic fine chemicals will also be introduced. In the last day, practice problems and interpretation of them will be carried out to confirm the level of understanding.
|Course schedule||Required learning|
|Class 1||Reactions via allyl metal complexes (1): allylic substitution reactions||Explain the allylic substitution reactions.|
|Class 2||Reactions via allyl metal complexes (2): isomerization reactions||Explain the isomerization reactions.|
|Class 3||Reactions via carbene complexes: cyclopropanation reactions, metathesis reactions||Explain the cyclopropanation reactions and metathesis reactions.|
|Class 4||Reactions via metallacycles (1): cycloaddition reactions||Explain the cycloaddition reactions.|
|Class 5||Reactions via metallacycles (2): cycloisomerization reactions||Explain the cycloisomerization reactions.|
|Class 6||Reactions via electrophilic activation of unsaturated bonds (1): functionalization reactions of alkenes||Explain the functionalization reactions of alkenes.|
|Class 7||Reactions via electrophilic activation of unsaturated bonds (2): functionalization reactions of alkynes||Explain the functionalization reactions of alkynes.|
|Class 8||Practice problems and interpretation for confirming the level of understanding||Solve practice problems by accurate understanding of the above all lectures.|
Practice problems and interpretation for confirming the level of understanding (85%), level of class participation (15%) (The level of class
participation will be calculated by discussion, small examination and so on in the lecture.)
The condition of the study will not be made, but it is desirable to study Advanced Chemistry of Transition Metal Complexes I & II,
Advanced Molecular Design of Metal Complexes I & II, or Advanced Coordination Chemistry.
This course can not be taken at the same time as CAP.I439"Organometallic Catalyst Chemistry".