[Summary of the course]
The instructor explains "reduction reactions (hydrogenation reactions, hydrosilylation reactions, and hydroboration reactions)", "oxidation reactions (epoxidation reactions, dihydroxylation reactions, and dehydrogenation reactions)", and "coupling reactions (carbon-carbon bond forming reactions, carbon-heteroatom bond forming reactions, carbonylation reactions, and carbon-hydrogen bond activation reactions)", which are especially important for applications to organic synthesis within organometallic catalyst chemistry.
[Aim of the course]
Organometallic catalysis chemistry is extremely important in not only laboratory organic synthesis but also industrial organic synthesis. In this course, various catalysis are classified and explained by the reaction mechanism. In addition, the development of catalytic asymmetric synthesis and application of these catalysis to the industrial synthesis of organic fine chemicals will also be introduced. Finally, students acquire the ability to apply organometallic catalysis to organic synthesis.
By the end of this course, students acquire the following ability:
(1) Ability to explain "reduction reactions" (hydrogenation reactions, hydrosilylation reactions, and hydroboration reactions).
(2) Ability to explain "oxidation reactions" (epoxidation reactions, dihydroxylation reactions, and dehydrogenation reactions).
(3) Ability to explain "coupling reactions" (carbon-carbon-bond forming reactions, carbon-heteroatom bond forming reactions, carbonylation reactions, and carbon-hydrogen bond activation reactions).
(4) Ability to apply organometallic catalysis (1)-(3) to organic synthesis.
Reduction reactions, hydrogenation reactions, hydrosilylation reactions, hydroboration reactions, oxidation reactions, epoxidation reactions, dihydroxylation reactions, dehydrogenation reactions, coupling reactions, carbon-carbon bond forming reactions, carbon-heteroatom bond forming reactions, carbonylation reactions, carbon-hydrogen bond activation reactions
|Intercultural skills||Communication skills||✔ Specialist skills||Critical thinking skills||✔ Practical and/or problem-solving skills|
This course covers reduction reactions, oxidation reactions, and coupling reactions, in that order. The instructor will also introduce examples of the catalytic asymmetric synthesis of optically active compounds, and examples of applying it to the industrial synthesis of organic fine chemicals as the need arises. In the final class, exercises and commentaries will be conducted to check understanding.
|Course schedule||Required learning|
|Class 1||Reduction reaction (1): Hydrogenation reactions||Explain the hydrogenation reaction.|
|Class 2||Reduction reaction (2): Hydrosilylation reactions, hydroboration reactions||Explain the hydrosilylation and hydroboration reactions.|
|Class 3||Oxidation reaction (1): Epoxidation reactions, dihydroxylation reactions||Explain the epoxidation and dihydroxylation reactions.|
|Class 4||Oxidation reaction (2): Dehydrogenation reactions||Explain the dehydrogenation reaction.|
|Class 5||Coupling reactions (1): Carbon-carbon and carbon-heteroatom bond forming reactions||Explain the carbon-carbon and carbon-heteroatom bond forming coupling reactions.|
|Class 6||Coupling reactions (2): Carbonylation reactions||Explain the carbonylation reaction.|
|Class 7||Coupling reactions (3): Carbon-hydrogen bond activation reactions||Explain the carbon-hydrogen bond activation reaction.|
|Class 8||Exercises and explanations for checking the students' understandings||Solve practice problems by accurate understanding of the above all lectures.|
Exercises for checking understanding (85%) and class participation (15%) (class participation is calculated from class discussions and quizzes)
The condition of the study will not be made, but it is desirable to study Advanced Chemistry of Transition Metal Complexes I & II,
Advanced Molecular Design of Metal Complexes I & II, or Advanced Coordination Chemistry.
Ken Tanaka: ktanaka[at]apc.titech.ac.jp
This course can not be taken at the same time as CAP.I 439 "Organometallic Catalyst Chemistry".