2018 Advanced Design of Organic Reaction Processes II

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Academic unit or major
Graduate major in Chemical Science and Engineering
Mikami Koichi 
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Course description and aims

[Summary of the lecture] In this lecture, various basic characteristics (electronic and steric effects) of organofluorine compounds and metal organofluorine reagents will be explained.
[Aim of the lecture] Organofluorine chemistry is of industrial and academic importance as pharmaceuticals and materials. Students understand basic characteristics of organofluorine compounds and their metal organofluorine, and then they acquire the ability to design new organofluorine compounds as promising pharmaceuticals and functional materials.

Student learning outcomes

By the end of this course, students acquire the ability to:
(1) design organofluorine compounds as potentially effective pharmaceuticals and functional materials.
(2) explain electronic and steric effects of organofluorine compounds and metal organofluorine reagents.


fluorinated drugs, fluorinated functional materials, electronic effect, steric effect, mimic effect, reaction mechanism, metalorganofluorine chemistry, fluorous chemistry

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

This lecture will proceed in the following order: electronic and steric effects, reaction mechanism, metalorganofluorine chemistry, fluorous chemistry. In the last day, practice problems and interpretation of them will be carried out to confirm the level of understanding.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Design of fluorinated drugs Design fluorinated drugs.
Class 2 Design of fluorinated functional materials Design fluorinated functional materials.
Class 3 Design of fluorinated ligands Design fluorinated ligands.
Class 4 Effective fluorofunctionalization Design fluorofunctionalization.
Class 5 Variety of building block and synthetic applications Design building blocks and synthetic applications.
Class 6 Fluorous chemistry:combinatorial and integrated synthesis Explain applications of fluorous chemistry in terms of combinatorial and integrated synthesis.
Class 7 Advanced metalorganofluorine chemistry: control of metal-fluorine interaction Explain how to control the metal-fluorine interaction.
Class 8 Practice problems and interpretation for confirming the level of understanding Solve practice problems by accurate understanding of the above all lectures.


Not specified

Reference books, course materials, etc.

Not specified

Assessment criteria and methods

Term-end examination (85%), level of class participation (15%) (The level of class participation will be calculated by discussion, small
examination and so on in the lecture.)

Related courses

  • CAP.A421.E: Advanced Chemistry of Transition Metal Complexes I
  • CAP.T431 : Advanced Organometallic Chemistry and Catalysis I

Prerequisites (i.e., required knowledge, skills, courses, etc.)

The condition of the study will not be made.

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