2017 Advanced Bioinorganic Chemistry II

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Academic unit or major
Graduate major in Chemical Science and Engineering
Kuwata Shigeki 
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Course description and aims

[Summary of the lecture] Advanced bioinorganic chemistry I and II systematically introduce bioinorganic chemistry. This course, advanced bioinorganic chemistry II, mainly covers the mechanisms of various metalloenzymes.
[Aim of the lecture] Bioinorganic chemistry, which describes the biological role of metal ions, is a rapidly growing research area. This course provides details of various metalloenzymes, which catalyzes biological transformations, based on the contents of advanced bioinorganic chemistry I. Transition metal complexes as inorganic medicine are also mentioned briefly.

Student learning outcomes

At the end of this course, students will be able to:
1) Explain the structures and mechanism of metalloenzymes.
2) Explain the mechanism of photosynthesis.


hydrolase, hydrogenase, nitrogen fixation, nitrogenase, nitrification, oxidase, photosynthesis

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

This course covers the structures and mechanisms of a variety of metalloenzymes. In the last day, final examination is set to assess the level of understanding.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Hydrolase Explain the mechanism of hydrolases.
Class 2 hydrogenases Explain the mechanism of hydrogenase.
Class 3 Nitrogen cycle Explain the nitrogen cycle in nature.
Class 4 Coordination chemistry relating to nitrogen fixation Explain transition metal complexes, which serve as structural and functional models of nitrogenase.
Class 5 Oxygen transfer reactions Explain the mechanism of oxidases.
Class 6 Photosynthesis Explain the mechanism of photosynthesis.
Class 7 Inorganic medicine Explain representative inorganic medicines.
Class 8 Practice problems to assess the level of understanding and explanation of the answers Understand the course contents and solve practice problems.


None required.

Reference books, course materials, etc.

R. R. Crichton, "Biological Inorganic Chemistry", 2nd Ed., Elsevier B. V.; ISBN: 978-0-4445-3782-9.
S. J. Lippard, J. M. Berg, "Principles of Bioinorganic Chemistry", University Science Books; ISBN: 978-0-9357-0272-9.
J. A. Cowan, "Inorganic Biochemistry: An Introduction", 2nd Ed., Wiley-VCH; ISBN: 978-0-4711-8895-7.
I. Bertini, H. B. Gray, E. I. Stiefel, J. S. Valentine, "Biological Inorganic Chemistry. Structure and Reactivity", University Science Books; ISBN: 978-1-8913-8943-2.
Course materials are provided during class.

Assessment criteria and methods

Final examination (70%), level of class participation (30%) which is assessed by small quizzes and so on.

Related courses

  • CAP.A465 : Advanced Bioinorganic Chemistry I
  • CAP.T431 : Advanced Organometallic Chemistry and Catalysis I
  • CAP.T432 : Advanced Organometallic Chemistry and Catalysis II
  • CAP.A561 : Advanced Chemistry of Transition Metal Complexes I
  • CAP.A562 : Advanced Chemistry of Transition Metal Complexes II

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students must have completed the 200- and 300-level basic courses offered by the Undergraduate major in Chemical Science and Engineering or have equivalent knowledge. Students are supposed to have knowledge of the contents of advanced bioinorganic chemistry I.

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