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2016　Advanced Design of Organic Reaction Processes I

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Academic unit or major
Graduate major in Chemical Science and Engineering
Instructor(s)
Mikami Koichi 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Fri1-2(S423)  
Group
-
Course number
CAP.A421
Credits
1
Academic year
2016
Offered quarter
1Q
Syllabus updated
2016/4/27
Lecture notes updated
-
Language used
English
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Course description and aims

[Summary of the lecture] In this lecture, organofluorine compounds are taught as promising drugs and materials. Electronic and steric effects of organofluorine compounds and metalorganofluorine compounds will be explained.
[Aim of the lecture] The organofluorine chemistry is extremely important in not only laboratory organic synthesis but also
industrial organic synthesis. In this lecture, various electronic and steric effects of organofluorine compounds and metal reagents will also be
introduced. Finally, students acquire the ability to design brand-new organofluorine compounds as promising drugs and materials.

Student learning outcomes

By the end of this course, students acquire the following ability to:
(1) design organofluorine compounds as promising drugs and materials.
(2) explain electronic and steric effects of organofluorine compounds and metalorganofluorine compounds

Keywords

organofluorine compounds, electronic effect, steric effect, mimic effect, reaction mechanism, metalorganofluorine chemistry, fluorous chemistry

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills ✔ Practical and/or problem-solving skills

Class flow

This lecture will proceed in the following order: electronic and steric effects, reaction mechanism, metalorganofluorine chemistry, fluorous chemistry. In the last day, practice problems and interpretation of them will be carried out to confirm the level of understanding.

Course schedule/Required learning

  Course schedule Required learning
Class 1 General introduction Explain electronic and steric effects of organofluorine compounds
Class 2 Common organofluorine compounds Explain the characteristic features of organofluorine compounds
Class 3 Origin of fluorine and organofluorine effects Explain the origin of fluorine and organofluorine effects
Class 4 Electronic effects of fluorine and physical properties and reactivities of organofluorine compounds Explain the physical properties and reactivities of organofluorine compounds
Class 5 Carbon-fluorine bond formation and activation Explain the importance of carbon-fluorine bond formation and activation
Class 6 Stereochemical features of organofluorine compounds Explain the stereochemical features of organofluorine compounds
Class 7 Synthesis of organofluorine compounds and metalorganofluorine reagents therewith Explain unique features of metalorganofluorine reagents
Class 8 Practice problems and interpretation for confirming the level of understanding Solve practice problems by accurate understanding of the above all lectures.

Textbook(s)

Mikami, K. Ed., Green Reaction Media in Organic Synthesis, Wiley-Blackwell, 2005　ISBN-13: 978-1-4051-3402-6

Reference books, course materials, etc.

Not specified

Assessment criteria and methods

Term-end examination (85%), level of class participation (15%) (The level of class participation will be calculated by discussion, small
examination and so on in the lecture.)

Related courses

  • CAP.A422 ： Advanced Design of Organic Reaction Processes I
  • CAP.T431 ： Advanced Organometallic Chemistry and Catalysis I

Prerequisites (i.e., required knowledge, skills, courses, etc.)

The condition of the study will not be made。

Contact information (e-mail and phone)    Notice : Please replace from "[at]" to "@"(half-width character).

mikami.k.ab[at]m.titech.ac.jp

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