2020 Advanced Biofunctional Chemistry I

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Academic unit or major
Graduate major in Chemical Science and Engineering
Instructor(s)
Tanaka Katsunori 
Course component(s)
Lecture     
Day/Period(Room No.)
Fri1-2(Zoom)  
Group
-
Course number
CAP.A425
Credits
1
Academic year
2020
Offered quarter
4Q
Syllabus updated
2020/11/30
Lecture notes updated
-
Language used
English
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Course description and aims

In this lecture, I will explain how the chemistry-based technologies, especially focusing on the synthetic organic chemistry, are applied to understand and regulate the biologically important processes. In "Advanced Biofunctional Chemistry I", the basic ideas and chemical technologies in this newly emerging field will be studied.

Student learning outcomes

By taking this lecture, students will understand the following basic ideas and technologies using synthetic organic chemistry.
(1) Labeling and bioconjugation
(2) Molecular imaging
(3) Understanding the in cell functions
(4) Activation of biologically active compounds and drugs

Keywords

Synthetic organic chemistry, molecular imaging, labeling, bioconjugation, in cell functions, biologically active compounds, drugs

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

This lecture proceed in the order of (1) labeling and bioconjugation, (2) molecular imaging, (3) understanding the in cell functions, and (4) activation of biologically active compounds and drugs. In the last round, exercises and commentary for confirming comprehension degree will be implemented.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Labeling and bioconjugation Explain the labeling and bioconjugation.
Class 2 Labeling and bioconjugation Explain the labeling and bioconjugation.
Class 3 Molecular imaging Explain the molecular imaging.
Class 4 Understanding the in cell functions Explain the methods for understanding the in cell functions
Class 5 Activation of biologically active compounds and drugs Explain the methods for activation of biologically active compounds and drugs
Class 6 Activation of biologically active compounds and drugs Explain the methods for activation of biologically active compounds and drugs
Class 7 Practice problems and interpretation for confirming the level of understanding Solve practice problems by accurate understanding of the above all lectures.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Although the lecture will be delivered on the basis of the following book, the reference materials will be delivered in advance and/or during each lecture.

Tanaka, K. and Vong, K., Handbook of In Vivo Chemistry in Mice: From Lab to Living System (Wiley-VCH) ISBN: 978-3-527-34432-1

Reference books, course materials, etc.

The additional materials will be delivered in advance and/or during each lecture.

Assessment criteria and methods

Practice problems and interpretation for confirming the level of understanding (90%), level of class participation (10%) (The level of class participation will be calculated by discussion, small examination and so on in the lecture).

Related courses

  • CAP.B214 : Organic Chemistry IV (Nucleophilic Substitution)
  • CAP.B315 : Organic Chemistry V (Carbonyl Compounds)
  • CAP.B316 : Organic Chemistry VI (Amines)
  • CAP.A332 : Advanced Organic Chemistry Ⅰ (Organic Reactions)
  • CAP.A334 : Advanced Organic Chemistry III (Organic Synthesis)

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Although there are no conditions for taking this course, it is desirable to take organic chemistry first to sixth, as well as advanced organic chemistry first and third.

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