Organotransition metal chemistry is closely related to the mechanism of synthetic organic reaction as well as of polymer synthesis from olefins using transition metal complexes as the catalyst. The complexes are regarded as the real intermediates of these catalytic reactions or as the model compounds of the intermediates. Quantitative discussion on the homogeneous and heterogeneous catalysis requires thorough understanding of the organotransition metal chemistry. This class contains two parts. The early part focuses on fundamental bonding, structures, and chemical properties of the organotransition metal complexes. The latter part covers the synthetic organic reactions using transition metal compounds as the catalyst. It involves not only scope and limitation of the recent synthetic organic reactions using transition metal catalysts but also role of the reactions in synthesis of organic compounds, including drugs, fundamentals, and materials. A few recent topics of research of this field are also included.
The undergraduate students will attain basic concepts of organotransition metal chemistry and current trends in synthetic organic chemistry using transition metal complexes as the catalysts.
By the end of this course, students will be able to:
1) Understand coordination bonds of organotransition metal complexes.
2) Explain the mechanism of reductive elimination, β-hydrogen elimination, and migratory insertion, and to mention relevance of the chemical properties of the organotransition metal complexes to homogeneous catalytic reactions.
3) Understand types and reaction mechanisms of homogeneous catalytic reactions such as hydrogenation, carbonylation, allylic substitution, cross-coupling reaction, and modern catalytic reactions.
homogeneous catalysis, organotransition metal chemistry, cross-coupling reaction, carbonylation
|✔ Specialist skills||Intercultural skills||Communication skills||Critical thinking skills||Practical and/or problem-solving skills|
Handout prepared by the instructors is used mainly. Simple quize is applied at the end of the class just for the students to check their understanding.
|Course schedule||Required learning|
|Class 1||Synthetic reactions of alkyltransition metal complexes and their chemical properties. Oxidative addtition and reductive elimination.||Explain preparation and structures of major alkyltransition metal complexes, oxidative addition, and reductive elimination|
|Class 2||Bonding of olefin complexes and carbonyl complexes. Insertion of olefin and of carbonyl ligands into a metal-alkyl bond, β-hydrogen elimination, and decarbonylation.||Explain π-back donation of olefin, carbonyl complexes、migratory insertion of olefin and carbonyl ligands into a M-C bond, and elimination of the small molecules.|
|Class 3||Bonding and chemical properties of π-allyl complex and carbene complex. Stoichiometric allylation and metathesis reactions. Properties of NHC ligands.||Explain difference of σ- and π-allyl complexes, their dynamic behavior, and reactivity of carbene complexes.|
|Class 4||Homogenous catalytic reactions (1)||Explain description of catalytic cycles on the basis of elementary reactions, principles and application of reactions of H2 and CO|
|Class 5||Homogenous catalytic reactions (2)||Explain principles and application of cross-coupling reaction|
|Class 6||Homogenous catalytic reactions (3)||Explain principles and application of allylic substitution reaction|
|Class 7||Homogenous catalytic reactions (4)||Explain modern catalytic reactions.|
|Class 8||Practice problems||Practice problems to assess the level of understanding and explanation of the answers|
Handout is delivered at every class
Score of final exam (100%).
Organic chemistry and inorganic chemistry of undergraduate level are required.
Kohtaro Osakada and Munetaka Akita: Contact by e-mail in advance to schedule an appointment.
It is inhibited to take both this class and either of the follwing two classes, CAP.T431"Advanced Organometallic Chemistry and Catalysis 1" and CAP.T432"Advanced Organometallic Chemistry and Catalysis 2".