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2018　Advanced Molecular Design for Organic Synthesis II

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Academic unit or major
Graduate major in Chemical Science and Engineering
Instructor(s)
Tanaka Hiroshi 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Fri3-4(H118)  
Group
-
Course number
CAP.A522
Credits
1
Academic year
2018
Offered quarter
4Q
Syllabus updated
2018/3/20
Lecture notes updated
-
Language used
Japanese
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Course description and aims

[Summary of Lecture] In this lecture, planning of the multi-step synthesis of complex organic compounds will be explained.
[The aim of the lecture] In the synthesis of complex organic compounds, it is important to design synthetic strategy consist of multiple reactions. In this lecture, students understand synthesis unsaturated hydrocarbon and functional group transformations. In addition, student learn the synthesis of the acyclic organic molecules with several functional groups. Then, students understand the synthesis of cyclic compounds, and learn about the synthesis of bicyclic molecule that features two fused rings. Furthermore, students discuss about their designed synthetic scheme themselves. Finally, students acquire the ability to design the synthetic scheme of small organic compounds.

Student learning outcomes

By the end of this course, students aquire the following ability
(1) Ability to explain the synthesis of unsaturated hydrocarbons.
(2) Ability to explain the synthesis of acyclic compounds having functional groups.
(3) Ability to explain the synthesis of cyclic compounds having functional groups.

Keywords

organic synthesis, multi-step synthesis, cyclic compounds, fused ring, acyclic compounds, double bond, triple bond, oxidation, reduction.

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills ✔ Practical and/or problem-solving skills

Class flow

In this course, the synthesis of unsaturated compounds and hydrocarbon compounds containing a functional group transformations will be explained. Based on the knowledge, students will be asked to propose the synthesis of acyclic compounds having functional groups and discuss with the other students about it. And then, the synthesis of cyclic compounds and cyclic compound having functional groups will be explained. Based on the knowledge, students will be asked to propose the synthesis of cyclic compounds having functional groups and discuss with the other students about it. In the last day, practice problems and interpretation of them will be carried out to confirm the level of understanding.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Synthesis of saturated hydrocarbons Explain synthesis of saturated hydrocarbons.
Class 2 Transformation of functional group Explain transformation of functional group.
Class 3 Synthesis of acyclic compounds with functional groups Explain synthesis of acyclic compounds with functional groups.
Class 4 Synthesis of 5- and 6-memmered cyclic compounds Explain synthesis of 5- and 6-memmered cyclic compounds.
Class 5 Synthesis of medium sized cyclic compounds Explain synthesis of medium sized cyclic compounds.
Class 6 Synthesis of cyclic compounds with several functional groups Explain synthesis of cyclic compounds with several functional groups.
Class 7 Synthesis of complex organic compounds Explain synthesis of complex organic compounds.
Class 8 Practice problems and interpretation for confirming the level of understanding Solve practice problems by accurate understanding of the above all lectures.

Textbook(s)

undecided

Reference books, course materials, etc.

Organic Synthesis: The Disconnection Approach, 2nd Edition Wily ISBN: 978-0-470-71236-8

Assessment criteria and methods

Term-end examination (85%), level of class participation (15%) (The level of class participation will be calculated by discussion, small examination and so on in the lecture.)

Related courses

  • CAP.A521 ： Advanced Molecular Design for Organic Synthesis I
  • CAP.A421 ： Advanced Design of Organic Reaction Processes I
  • CAP.A422 ： Advanced Design of Organic Reaction Processes I
  • CAP.T431 ： Advanced Organometallic Chemistry and Catalysis I
  • CAP.T432 ： Advanced Organometallic Chemistry and Catalysis II
  • CAP.A423 ： Advanced Organic Synthesis I
  • CAP.A424 ： Advanced Organic Synthesis II

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students should take Advanced Molecular Design for Organic Synthesis I (CAP.A521). It is desirable to study Advanced Design of Organic Reaction Processes I & II (CAP.A421・CAP.A422) or Advanced Organic Synthesis I & II (CAP.A423・CAP.A424)

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