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- 工学院，物質理工学院，環境・社会理工学院共通科目
- Liberal arts and basic science courses
- First-Year Courses
- School of Science
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- School of Life Science and Technology
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School of Environment and Society
- Department of Architecture and Building Engineering
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- Graduate major in Technology and Innovation Management
- Common courses
- Liberal arts and basic science courses
- Academic unit or major
- Graduate major in Life Science and Technology
- Instructor(s)
- Hirasawa Takashi Shiraki Nobuaki Yamamoto Naoyuki Kato Akira
- Class Format
- Lecture
- Media-enhanced courses
- Day/Period(Room No.)
- Tue1-2(J221,W833) Fri1-2(J221,W833)
- Group
- -
- Course number
- LST.A407
- Credits
- 2
- Academic year
- 2019
- Offered quarter
- 3Q
- Syllabus updated
- 2019/3/18
- Lecture notes updated
- -
- Language used
- English
- Access Index
-
Course description and aims
Cellular metabolism is required to obtain the energy for growth and is closely related to cellular responses and diseases. This course will provide an overview of cellular responses and diseases in microorganisms and animals from a viewpoint of metabolism.
The aim of this course is to learn the cellular responses and diseases in organisms and application of their knowledge to the fields of engineering and medical science.
Student learning outcomes
At the end of this course, students will be able to:
1) Understand the metabolic regulations in microbial cells and explain the technologies and examples of bioproduction using microbial cells.
2) Understand the intestinal microflora and impact on host throughout host-microbe communication.
3) Understand the role of the urinary, gastrointestinal, muscular and endocrine systems in mammalian water-electrolyte and energy metabolisms and the mechanisms of related diseases.
4) Understand the metabolic regulations in stem cells and explain cell differentiation technology and therapy utilizing its characteristics.
Keywords
Microorganisms, Metabolic engineering, Bioproduction, Probiotic bacteria, Commensal bacteria, Symbiotic bacteria, Water-electrolyte metabolism, Energy metabolism, Organ function, Stem cell, Amino acid metabolism, Regenerative medicine
Competencies that will be developed
| ✔ Specialist skills | Intercultural skills | Communication skills | ✔ Critical thinking skills | ✔ Practical and/or problem-solving skills |
Class flow
Students should familiarize themselves with topics described in the required learning section before coming to the class. Students might be given exercise problems related to what is taught on that day to solve.
Course schedule/Required learning
| Course schedule | Required learning | |
|---|---|---|
| Class 1 | What is metabolic engineering? | Explain the definition of metabolic engineering and methodology of metabolic engineering |
| Class 2 | Metabolic engineering for bioproduction | Study the strategies for bioproduction using microbial cells and recent progresses of bioproductions |
| Class 3 | Metabolic flux analysis 1 | Understand the methodology for analyzing intracellular metabolic fluxes |
| Class 4 | Metabolic flux analysis 2 | Understand the methodology for estimation of metabolic flux ratio using 13C-labeled substrate(s) |
| Class 5 | Microflora analysis | Understand the intestinal microflora and the analytical method |
| Class 6 | Host-microbe relationship | Understand the impact of intestinal microbe on host |
| Class 7 | Controlling of the intestinal microflora | Understand current topics for the controlling of the intestinal microflora |
| Class 8 | Water-electrolyte metabolism in mammals | Understand the role of the kidney and intestine in water-electrolyte metabolism at molecular, cellular and tissue level. |
| Class 9 | Regulation of water-electrolyte metabolism and diseases | Study the endocrine regulation of water-electrolyte metabolism and related diseases. |
| Class 10 | Energy metabolism in mammals | Understand the role of the intestine, liver, adipose tissue and skeletal muscle in energy metabolism at molecular, cellular and tissue level. |
| Class 11 | Regulation of energy metabolism and diseases | Study the endocrine regulation of energy metabolism and related diseases. |
| Class 12 | Overview of stem cell metabolism | Review the enagy metabolism in embryonic and somatic stem cells |
| Class 13 | Glucose metabolism of stem cells | Review the glucose metabolism studied in undergraduate major courses in Life Science and Technology, and understand the glucose metabolism of stem cells |
| Class 14 | Amino acid metabolism of stem cells | Understand the amino acid metabolism of stem cells, and its role in the pluripotency and differentiation of stem cells |
| Class 15 | Stem cell metabolism for regenerative medicine | Understand the regenerative medicine research using unique metabolic properties of stem cells |
Textbook(s)
None required.
Reference books, course materials, etc.
Course materials are provided through OCW-i.
Assessment criteria and methods
Each instructor will give report assignment related to the lecture. Based on your submitted reports, students will be assessed on their achievements described in "Student learning outcomes."
Related courses
- 400-level graduate major courses in Life Science and Technology
Prerequisites (i.e., required knowledge, skills, courses, etc.)
No prerequisites are necessary, but it is desirable to have basic knowledge of biochemistry, molecular biology and cell biology.
Other
This course will follow from the basic to advanced levels. For Japanese students, outline of the class will be explained in Japanese at the end of the class.
