[Summary of the lecture] In this lecture, the importance of pharmaceutial and agrochemical sciences will be taught for the students who studied Advanced Organic Chemistry I - IV.
[Aim of the lecture] The stereochemistry is important in understanding biochemistry and essential to analyze the mechanism of various biologically activity of organic compounds. Students understand phenomena of optical and biologically activities of molecules and then the synthesis of biologically activite molecules based on the development of stereoselective organic reactions.
By the end of this course, students acquire the ability:
(1) Ability to explain the importance of pharmaceutials and agrochemicals.
(2) Ability to explain the molecular design of biologically active compounds.
(3) Ability to explain the development of stereoselective reactions for the synthesis of biologically active compounds.
pharmaceuticals, agrochemicals, optical activity, biological activity, stereoselective reactions, physiological mechanisms
|✔ Specialist skills||Intercultural skills||Communication skills||✔ Critical thinking skills||✔ Practical and/or problem-solving skills|
This lecture will proceed in the following order: (1) development of stereoselective synthetic reactions and synthesis of biological active molecules, (2) development of molecular probes and exploitation of the drug target, (3) natural products and development of bio-probes, (4) molecular biology and clinical medicine.
|Course schedule||Required learning|
|Class 1||Optical Activity and Biological Activity||Explain an optical activity and biological activity.|
|Class 2||Development of Stereoselective Reactions and Synthesis of Biologically Active Molecules||Explain development of stereoselective organic reactions.|
|Class 3||Development of probes and Exploitation of Drug Targets||Understand the importance of new probe targeted for new protein.|
|Class 4||Exploitation of Target Protein and Inhibitory Activity||Understand the importance of targeting proteins and finding inhibitors thereof.|
|Class 5||Natural Products and Bio-Probes||Understand the importance of atural product bank and bio-probe thereof.|
|Class 6||Chemical Biology||Understand the importance of chemical biology (interface of organic chemistry and biology).|
|Class 7||Molecular Biology||Understand the importance of molecular biology for drug design.|
|Class 8||Molecular Biology（２）||Understand the importance of molecular biology for drug design.|
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
Practice problems and interpretation for confirming the level of understanding (85%), level of class participation (15%).
The condition of the study will not be made, but it is desirable to study Advanced Organic Chemistry I - IV.