2018 Advanced Organic Chemistry V (Drug Design and Synthesis)

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Academic unit or major
Undergraduate major in Chemical Science and Engineering
Mikami Koichi  Toyohara Jun  Ishihara Kazuaki  Tomita Taisuke 
Class Format
Media-enhanced courses
Day/Period(Room No.)
Intensive ()  
Course number
Academic year
Offered quarter
Syllabus updated
Lecture notes updated
Language used
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Course description and aims

[Summary of the lecture] In this lecture, the importance of pharmaceutial and agrochemical sciences will be taught for the students who studied Advanced Organic Chemistry I - IV.
[Aim of the lecture] The stereochemistry is important in understanding biochemistry and essential to analyze the mechanism of various biologically activity of organic compounds. Students understand phenomena of optical and biologically activities of molecules and then the synthesis of biologically activite molecules based on the development of stereoselective organic reactions.

Student learning outcomes

By the end of this course, students acquire the ability:
(1) Ability to explain the importance of pharmaceutials and agrochemicals.
(2) Ability to explain the molecular design of biologically active compounds.
(3) Ability to explain the development of stereoselective reactions for the synthesis of biologically active compounds.


pharmaceuticals, agrochemicals, optical activity, biological activity, stereoselective reactions, physiological mechanisms

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

This lecture will proceed in the following order: (1) development of stereoselective synthetic reactions and synthesis of biological active molecules, (2) development of molecular probes and exploitation of the drug target, (3) natural products and development of bio-probes, (4) molecular biology and clinical medicine.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Optical Activity and Biological Activity Explain an optical activity and biological activity.
Class 2 Development of Stereoselective Reactions and Synthesis of Biologically Active Molecules Explain development of stereoselective organic reactions.
Class 3 Development of probes and Exploitation of Drug Targets Understand the importance of new probe targeted for new protein.
Class 4 Exploitation of Target Protein and Inhibitory Activity Understand the importance of targeting proteins and finding inhibitors thereof.
Class 5 Natural Products and Bio-Probes Understand the importance of atural product bank and bio-probe thereof.
Class 6 Chemical Biology Understand the importance of chemical biology (interface of organic chemistry and biology).
Class 7 Molecular Biology Understand the importance of molecular biology for drug design.
Class 8 Clinical Medicine Understand the importance of clinical medicine for drug development.


Not specified.

Reference books, course materials, etc.

Not specified.

Assessment criteria and methods

Practice problems and interpretation for confirming the level of understanding (85%), level of class participation (15%).

Related courses

  • CAP.A231 : Advanced Organic Chemistry I (Organic Reactions)
  • CAP.A332 : Advanced Organic Chemistry II (Organic Reactions)
  • CAP.A333 : Advanced Organic Chemistry III (Structure and Function)
  • CAP.A334 : Advanced Organic Chemistry IV (Organic Synthesis)

Prerequisites (i.e., required knowledge, skills, courses, etc.)

The condition of the study will not be made, but it is desirable to study Advanced Organic Chemistry I - IV.

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