2018 Advanced Organic ChemistryⅡ (Structure and Function)

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Academic unit or major
Undergraduate major in Chemical Science and Engineering
Ito Shigekazu  Tanaka Ken 
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Course description and aims

[Summary of the course] In this course, fundamental chemistry of heterocyclic compounds including medicines will be explained.
[Aim of the course] Many functional organic compounds such as medicines, biologically active compounds, and electronic materials are composed of heterocyclic structures. In this course, students learn fundamentals of heterocyclic chemistry, and acquire the ability to design functional organic compounds.

Student learning outcomes

By the end of this course, students acquire the following abilities to:
(1) Classify heterocyclic compounds, and explain the nomenclature.
(2) Explain synthesis and reactions of 5- and 6-membered heterocyclic compounds.
(3) Explain the importance of heterocyclic structures for nucleic acids, vitamins and the like.


heterocyclic compounds, cyclizations, cycloadditions, nucleophilic aromatic substitution, electrophilic aromatic substitution, aromaticity, biological activity

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

This course will proceed in the following order: (1) classification and nomenclature of heterocyclic compounds, (2) synthesis and reactions of 5- and 6-membered heterocyclic compounds, (3) chemistry of nucleic acids and vitamins. In the last day, practice problems and interpretation of them will be carried out to confirm the level of understanding.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Classification and nomenclature of heterocyclic compounds Classify heterocyclic compounds and understand the nomenclature.
Class 2 General aspects of heterocyclic compounds Explain general aspects of heterocyclic compounds.
Class 3 Palladium catalysis in the synthesis of heterocyclic compounds Explain importance of palladium-catalyzed reaction for synthesis heterocyclic compounds.
Class 4 Chemistry of furans and thiophenes Explain synthesis and reactions of fused five-membered heterocyclic compounds.
Class 5 Chemistry of pyrylium and pyrones Explain chemistry of O-containing six-membered heterocyclic compounds.
Class 6 Chemistry of non-aromatic heterocyclic compounds Explain chemistry of non-aromatic (saturated) heterocyclic compounds.
Class 7 Nucleic acids, vitamins, materials Explain properties and functionality of nucleic acids, vitamins, and materials.
Class 8 Practice problems and interpretation for confirming the level of understanding Solve practice problems by accurate understanding of the above all lectures.


None required.

Reference books, course materials, etc.

Heterokan no Kagaku - Kiso to Ouyou (Tokyo Kagaku Dojin) ISBN 978-4-8079--8790
McMurry Organic Chemistry, international edition of 9th revised edition (Cengage Learning) ISBN-13: 978-4-8079-09148

Assessment criteria and methods

Practice problems and interpretation for confirming the level of understanding (90%), level of class participation (10%) (The level of class
participation will be calculated by discussion, small examination and so on in the lecture.)

Related courses

  • CAP.B212 : Organic Chemistry II (Alkenes)
  • CAP.B213 : Organic Chemistry III (Aromatic Compounds)
  • CAP.B214 : Organic Chemistry IV (Nucleophilic Substitution)
  • CAP.B315 : Organic Chemistry V (Carbonyl Compounds)
  • CAP.B316 : Organic Chemistry VI (Amines)
  • CAP.B211 : Organic Chemistry I (Alkanes) (Chemical Science and Engineering)

Prerequisites (i.e., required knowledge, skills, courses, etc.)

The condition of the study will not be made, but it is desirable to study Organic Chemistry I (Alkanes) (Chemical Science and Engineering),
Organic Chemistry II (Alkenes), Organic Chemistry III (Aromatic Compounds), Organic Chemistry IV (Nucleophilic Substitution), and Organic Chemistry VI (Amines).

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