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2019　Advanced Bioorganic Chemistry

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Academic unit or major
Graduate major in Chemistry
Instructor(s)
Eguchi Tadashi 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Mon5-6(H118)  Thr5-6(H118)  
Group
-
Course number
CHM.D431
Credits
2
Academic year
2019
Offered quarter
4Q
Syllabus updated
2019/3/18
Lecture notes updated
-
Language used
English
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Course description and aims

Bioorganic chemistry studies the chemistry of organic biomolecules. It is a rapidly growing interdisciplinary field that combines organic chemistry and biochemistry. Bioorganic chemistry aims to expand organic-chemical research on structures, biological activity, and mechanism of action. This one-semester course will cover several advanced chemistry topics and will discuss the chemistry behind biological processes.

Student learning outcomes

The aim of the course is that the student will have good knowledge about the structure and biological activity of organic compounds, and know how to use acquired knowledge about the mechanism of action reaction mechanisms of biologically interesting substances such as pharmacologically active compounds.

Keywords

biological active compound, mechanism of action

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Lectures

Course schedule/Required learning

  Course schedule Required learning
Class 1 What is biologically active compounds? What is biologically active compounds?
Class 2 Reaction in biological system, chemistry of enzyme and coenzymes Understanding of biological reactions, enzyme, amino acids, co-enzymes.
Class 3 Antibiotics (β-lactams) Understanding of chemistry of β-lactam antibiotics.
Class 4 Antibiotics (aminoglycosides) Understanding of chemistry of aminoglycosides antibiotics.
Class 5 Antibiotics (macrolides and tetracyclines) Understanding of chemistry of macrolides and tetracyclines antibiotics.
Class 6 Antibiotics (others) Understanding of chemistry of other antibiotics.
Class 7 Antifungal agents Understanding of chemistry of antifungal agents.
Class 8 Antitumor agents (alkylating agents) Understanding of chemistry of alkylating agents.
Class 9 Antitumor agents (antitumor antibiotics) Understanding of chemistry of antitumor antibiotics.
Class 10 Antitumor agents (antimetabolic agents） Understanding of chemistry of antitumor antimetabolic agents.
Class 11 Antitumor agents (plant metabolites and others） Understanding of chemistry of anti tumor plant metabolites and others.
Class 12 Cholesterol lowering agents Understanding of chemistry of cholesterol lowering agents.
Class 13 Antihypertensive agents (angiotensin converting enzyme inhibitors and angiotensin receptor blockers) Understanding of chemistry of angiotensin converting enzyme inhibitors and angiotensin receptor blockers.
Class 14 Antihypertensive agents (Ca channel blockers) Understanding of chemistry of Ca channel blockers.
Class 15 Antiviral agents Understanding of chemistry of antiviral agents.

Textbook(s)

None

Reference books, course materials, etc.

Prints

Assessment criteria and methods

Exercise problems including homework in each class (30%) and a final report (70%)

Related courses

  • CHM.D334 ： Natural Product Chemistry
  • CHM.D401 ： Basic Concepts of Organic Chemistry

Prerequisites (i.e., required knowledge, skills, courses, etc.)

An understanding of the fundamentals of organic chemistry is required for this course.

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