This course will focus on the basic and advanced organic synthesis.
The first half of the course (lectured by Inoue) will mainly cover the synthesis of organo fine chemicals including drugs, agrochemicals, liquid crystals, and functionalized compounds. With studying C-C bond formation reactions and functional group transformations, students will understand the reaction mechanism and the reaction intermediate and learn how to draft the synthetic plan for targeted molecules.
The second half of the course (lectured by Matsukawa) will deal with organic polymers by some polymerization methods. Furthermore, this lecture will present the preparation and properties of organic-inorganic hybrids and their applications.
By the end of this course, students will be able to:
１）understand organic reactions based on the reaction intermediate and the reaction mechanism.
２）draft the synthetic plan toward organo fine chemicals.
３）understand organic polymers with polymerization methods and design for new functional materials.
４）understand the basics and applications of organic-inorganic hybrids.
Organic synthesis, organic reaction, reaction intermediate, reaction mechanism, organo fine chemicals, organic polymers, polymerization, organic-inorganic hybrid
|✔ Specialist skills||Intercultural skills||Communication skills||Critical thinking skills||✔ Practical and/or problem-solving skills|
In the first half of the class, a summary of the previous lecture followed by the main points of the day's lecture are given. In the latter half, these main points are discussed in detail. Students are asked to provide solutions to some of the questions that have been given as necessary.
|Course schedule||Required learning|
|Class 1||Introduction: Organic Synthesis||Understand the history of organic synthesis, the reaction mechanism, and reaction intermediates|
|Class 2||C-C Bond formation by using carbanion (1)||Understand the property, the generation method, and the reactivity of carbanions|
|Class 3||C-C Bond formation by using carbanion (2)||Learn examples of the synthesis of fine chemicals using carbanions|
|Class 4||C-C Bond formation by using carbocation||Understand the property, the generation method, and the reactivity of carbocations|
|Class 5||C-C Bond formation by using radical||Understand the property, the generation method, and the reactivity of radicals|
|Class 6||C-C Bond formation by using carbene||Understand the property, the generation method, and the reactivity of carbenes|
|Class 7||Functional group transformations||Learn functional group transformations|
|Class 8||Industrial chemistry||Understand the application of organic synthesis in the industry|
|Class 9||Introduction of synthetic polymers||Undersand the history of synthetic polymers and their industrial applications|
|Class 10||Polymerizations and characterization of organic polymers||Understand the veriety of polymerization and characterization|
|Class 11||Funtions and properties of organic polymers||Understand the funtions and properties based on the structure of organic polymers|
|Class 12||Preparation of network polymers and their properties||Understand thermal and photo-assisted network polymers and their properties|
|Class 13||Preparation and properties of organic-inorganic hybrid materials||Understand the preparation and properties of organic-inorganic hybrid materials|
|Class 14||Nano materials for organic-inorganic hybrid materials||Understand nano materials for prepation of organic-inorganic hybrid materials|
|Class 15||Application of organic-inorganic hybrid materials||Learn the application of organic-inorganic hybrid materials|
F. A. Carey and R. J. Sundberg 「Advanced Organic Chemistry: Part B」 Plenum Press, ISBN-13: 978-0387683546
Handouts will be provided.
Students are assessed based on
activities in class: 50%