2016 Advanced Biosensing Systems

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Academic unit or major
Fukui Toshiaki  Kamachi Toshiaki  Asakura Noriyuki  Ogura Shunichiro  Mori Toshiaki  Kobatake Eiry  Kajikawa Kotaro  Nakamoto Takamichi  Sandhu Adarsh  Ishida Hiroshi 
Course component(s)
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Day/Period(Room No.)
Intensive ()  
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Syllabus updated
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Course description and aims

In this course we will cover physical sensors and chemical sensors related to medicine, measuring technology that uses them, and a wide range of biomeasurement technology related to biomolecules and biological environments. First the instructor will teach the basics of molecular biology for students not in the biology field. Then the instructor will go over microbial genome analysis, optical oxygen sensing, smart sensors, biological electron transfer reactions, biosensors that use magnetic bodies, robotic engineering, cancer imaging, protein engineering for biosensing, surface plasmons, and single-molecule measurements.

Student learning outcomes

By the end of this course, students will be able to:
1. Understand the fundamentals of molecular biology
2. Acquire advanced knowledge for bases and applications of various biosensing technologies


Molecular biology, Oxygen sensing, Smart sensor, Biological electron transfer reaction, Magnetic biophysics, Robotics, Cancer, Protein Engineering, Surface plasmon, Single molecule detection, Biomolecular reaction

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

10 instructors are responsible for one lecture each, and will explain the content using PowerPoint.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Fundamentals of molecular biology, and genome analysis of microbes (Fukui) Understand the fundamentals of molecular biology, and explain the notion and methodologies of genome analysis of microbes.
Class 2 Optically-based oxygen sensing (Kamachi) Understanding the principle of the quenching of photoexcited state by oxygen.
Class 3 Odor Sensing System (Nakamoto) Understand the fundamentals of odor sensing system and develop his/her attitude toward interdisciplinary study.
Class 4 Measurement of biological electron transfer using electrochemical techniques (Asakura) Understand redox reaction of proteins, and explain the principle of electrochemical measurement.
Class 5 Biosensors using magnetic materisl (Sandhu) Explain the fundamentals of medical diagnostics based on magnetic sensors and magnetic particles.
Class 6 Olfactory search behavior of animas and its application to robotic sensing (Ishida) Explain the mechanisms of olfactory search behavior of animals and the applications of robots that mimic the animal behavior.
Class 7 Cancer diagnosis and therapy (Ogura) Explain the basis and applications of cancer diagnosis/therapy.
Class 8 Protein Engineering for Biosensing (Kobatake) Explain the design of proteins for construction of biosensing systems.
Class 9 Surface Plasmon Biosensing (Kajikawa) Understand the principle and applications of surface-plasmon biosensing.
Class 10 Method of measuring biomolecular reaction at single molecule level (Mori) Understand the mechanism of interaction between biomolecules, and explain the novel method for detecting of biomolecular reactions.



Reference books, course materials, etc.

Materials are distributed as needed at the beginning of lecture. PowerPoint slides used in lecture are uploaded to OCWi in advance when possible.

Assessment criteria and methods

Students course scores are based on short exams carried out in the end of each class.

Related courses

  • none

Prerequisites (i.e., required knowledge, skills, courses, etc.)



This course is provided as a course in "Medical and Dental Engineering Special Course" held by Joint Program between Tokyo Institute of Technology - Tokyo Medical and Dental University. This course will be opened at Campus Innovation Center (Tamachi Campus) in specific week(s) in August-October. One class is 135 min. The detailed schedule will be available in HP of this special course.

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