In this course, students operate instruments for mass spectrometry and NMR to determine the structures of organic molecules. Then, students attempt to solve the structure of the target molecules based on the mass and NMR data. The lecturers teach how to operate these instruments and how to analyze the obtained data. We discuss about the strategy for structural determination of organic molecules.
Nowadays, mass and NMR (including 2D NMR) analysis are widely taken for structural determination of relatively small organic molecules. Students will be able to take such spectra by themself and analyze the data for structural determination.
By the end of this course, students will be able to:
1) Determine the structure of relatively small organic molecules.
2) Operate instruments for mass and NMR by themself
3) Analyze mass spectra and NMR spectra including 2D NMR data for structural determination
Structural analysis of organic molecules, structure determination, mass spectral analysis, NMR, 2D-NMR
|Intercultural skills||Communication skills||✔ Specialist skills||Critical thinking skills||✔ Practical and/or problem-solving skills|
In the first half of the class, we will discuss about previous spectral analysis taken by students. In the latter half, the lecturer teaches a main topic according to the course schedule. Students analyze mass spec and NMRs outside of the classroom.
|Course schedule||Required learning|
|Class 1||Introduction to structural analysis of organic compounds||Decide a target sample for analysis|
|Class 2||Mass spectral analysis of organic compounds||Mass spectral analysis and make a report|
|Class 3||1H-NMR||1H-NMR analysis and make a report|
|Class 4||13C-NMR||13C-NMR analysis and make a report|
|Class 5||COSY||COSY analysis and make a report|
|Class 6||HMQC, HMBC||HMQC, HMBC analysis and make a report|
|Class 7||NOE||NOE analysis and make a report|
|Class 8||Structural determination of organic compounds||Final report|
Course materials are provided during class.
Spectrometric Identification of Organic Compounds
Exercise problems in each class (60%) and a final report (40%)
No prerequisites are necessary. But, students who have a credit for Practical Exercises for Advanced Instrumental Measurements I or Practical Exercises for Advanced Instrumental Measurements II, cannot take this class.
Fumitaka Kudo: fkudo[at]chem.titech.ac.jp
Students may approach the instructors at the end of class or contact by e-mail in advance to schedule an appointment.