2021 Biomaterial Science and Engineering

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Academic unit or major
Graduate major in Life Science and Technology
Instructor(s)
Tagawa Yoh-Ichi  Maruyama Atsushi  Mori Toshiaki  Matsuda Tomoko  Kinbara Kazushi 
Course component(s)
Lecture    (ZOOM)
Day/Period(Room No.)
Mon3-4()  Thr3-4()  
Group
-
Course number
LST.A412
Credits
2
Academic year
2021
Offered quarter
1Q
Syllabus updated
2021/3/22
Lecture notes updated
-
Language used
English
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Course description and aims

Biomaterials Engineering involves introduction to anatomy of human tissues and organs, biomaterials science, artificial organs, prosthetic devices, and in vitro living models using microfluidic devices. Biomaterials include polymeric, ceramic, metallic, and other biomimetic materials. At the end of this course, students will be able to: 1) Explain biomaterials. 2) Have an understanding of living body and its reactions, design biomaterials for research and medicine. 3) Design and experiment or draw up research plans, collect and analyze the data obtained , and produce reports based on the findings. 4) Prepare overviews of previously conducted researches, identify issues, and propose solutions.

Student learning outcomes

By the end of this course, students will be able to:
1) Use the techniques and modern engineering tools for basic and clinical biomedical study.
2) Understand the properites and applications of biomaterials, both natural and synthetic.
3) Understand the interactions between biomaterials and the human body.Understand how to use biomaterial engineering.

Keywords

Biomaterial, Matrix, Organ, Tissue, Tissue Engineering, Cell, Regenerative Medicine, Drug Delivery

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

In the first quarter of a class, a summary of the previous lecture followed by the main points of the day’s lecture posed as questions are given. Then, these main points are discussed in detail. Always check the required learning for each class and be sure to complete them as a part of preparation and review.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Cells, tissues and organs in body, Clinical and pharmaceutical applications, safety, and sterilization of bio-materials Students will understand the aims of this course. Student will be introduced to structures of tissues, including cell-cell and cell-scaffold adherences, and organs as outline of human anatomy. Students will be provided with an overview of current regenerative medicine using biomaterial technology.
Class 2 Cell adhesion, Cell culture substrates and decellularization Students will understand principles of cell adhesion in molecular level and applications of cell cultures as regenerative medicine
Class 3 Tissue/Organ/Body chip Students will understand basics of cell culture on microfluidic device, and application to alternatives of animal experiments and clinical studies.
Class 4 Analyses of structure on cell surfaces Students will be introduced to understand nano-scale structure on cell surfaces for biomaterials.
Class 5 Bionanotechnology Students will be introduced to understand nanotechnology for biomaterials.
Class 6 Protein-based biomaterials Student will be introduced to 1) properties and applications of structural proteins, and 2) preparation and applications of bioconjugates.
Class 7 Nucleic acid-based biomaterials Students will be provided with applications of nucleic acids for fabrication of nano-materials.
Class 8 Biomimetic materials Student will be introduced to concept and examples of biomimetic materials.
Class 9 Fundamentals of drug delivery system Students will be provided with fundamentals of drug delivery systems
Class 10 Biomaterials for drug delivery systems Student will be introduced polymer materials used for drug delivery systems.
Class 11 Polymer complexes for biomolecular engineering Student will understand biomolecular engineering using polymer complexes.
Class 12 Organic/polymer synthesis using biocatalysis Students will understand basics of biocatalysis for organic/polymer synthesis.
Class 13 Application of biocatalysis to biomaterial synthesis Students will be introduced to application of biocatalysis to biomaterial synthesis.
Class 14 Biomaterial synthesis using supercritical fluid Students will understand basics of supercritical fluid technology and its application to the biomaterial synthesis.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Essential Biomaterials Science, David Williams, Cambridge University Press

Reference books, course materials, etc.

Molecular Biology of the Cell, 6th Edition (Bruce Alberts et al., Garland Science)
Biochemistry, 4th Edition (Donald Voet, Judith G. Voet, Wiley)

Assessment criteria and methods

1) Students will be assessed on their understanding of each tiopic
2) Students' course scores are based on the exams or reports of each professor.
3) Full attendance are compulsory.

Related courses

  • LST.A203 : Biochemistry I
  • LST.A218 : Biochemistry II
  • LST.A208 : Molecular Biology I
  • LST.A213 : Molecular Biology II
  • LST.A336 : Genetic Engineering
  • LST.A342 : Biomedical Materials

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Biochemistry, Molecular Biology, Cell Biology, General Chemistry

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