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2023　Advanced Bioorganic Chemistry

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Academic unit or major
Graduate major in Chemistry
Instructor(s)
Kudo Fumitaka 
Class Format
Lecture    (Face-to-face)
Media-enhanced courses
Day/Period(Room No.)
Mon3-4(M-B43(H106))  Thr3-4(M-B43(H106))  
Group
-
Course number
CHM.D431
Credits
2
Academic year
2023
Offered quarter
3Q
Syllabus updated
2023/3/20
Lecture notes updated
-
Language used
English
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Course description and aims

The student will learn how they understand and consider the biological events in living cells in terms of organic chemistry. To do so, the student will learn structures and functions of DNA, RNA, proteins, glycans, lipids based on organic chemistry. Particularly, the student will learn how low molecular weight compounds interact with the biomolecules resulting in better understanding of the biological events.

Student learning outcomes

The aim of the course is that the student will understand and consider the structure and function of biomolecules including DNA, RNA, proteins, glycans, polyketides, terpenoids in terms of organic chemistry. The student will understand how low molecular weight compounds interact with the biomolecules resulting in better understanding of the biological events.

Keywords

chemical biology, mode of action, interaction between biomolecules and small molecules, DNA, RNA, peptides, proteins, glycans, polyketides, terpenoids, signal transduction, receptor proteins

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Lectures

Course schedule/Required learning

  Course schedule Required learning
Class 1 Introduction to bioorganic chemistry and chemical biology Overview of chemical biology
Class 2 The chemical origins of biology Understanding of the chemical origins of biology
Class 3 DNA structure and function Understanding of DNA structure and function
Class 4 DNA as a target for drugs Understanding of DNA as a target for drugs
Class 5 RNA structure and function Understanding of RNA structure and function
Class 6 Translational system as a target for drugs Understanding of translational system as a target for drugs
Class 7 Peptide and protein structure Understanding of peptide and protein structure
Class 8 Protein function Understanding of protein function
Class 9 Enzyme reactions and inhibitors Understanding of enzyme reactions and inhibitors
Class 10 Glycobiology Understanding of glycobiology
Class 11 Polyketides chemistry Understanding of polyketides chemistry
Class 12 Terpenoids Understanding of terpenoids chemistry
Class 13 Fundamental of signal transduction Understanding of fundamental of signal transduction
Class 14 Receptor proteins and small molecules in signal transduction Understanding of receptor proteins and small molecules in signal transduction

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

None

Reference books, course materials, etc.

”Introduction to bioorganic chemistry and chemical biology” CRC Press (Taylor & Francis Group)
related pdfs would be distributed.

Assessment criteria and methods

Exercise problems including homework in each class (30%) and a final exam (70%)

Related courses

  • CHM.D334 ： Natural Product Chemistry
  • CHM.D401 ： Basic Concepts of Organic Chemistry

Prerequisites (i.e., required knowledge, skills, courses, etc.)

An understanding of the fundamentals of organic chemistry is required for this course.

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