2017 Biotechnology Laboratory II 分子

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Academic unit or major
Biotechnology
Instructor(s)
Masuda Shinji 
Course component(s)
Day/Period(Room No.)
Tue5-8(緑が丘3号館学生実験室)  Fri5-8(緑が丘3号館学生実験室)  
Group
分子
Course number
ZUX.D322
Credits
4
Academic year
2017
Offered quarter
3-4Q
Syllabus updated
2017/9/6
Lecture notes updated
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Language used
Japanese
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Course description and aims

Chemical structure and a basic concept about the biochemical significance of the nucleic acid, protein, and polysaccharide as biopolymers, are reviewed. After having done the statement about the general property of biopolymers, the structure and the function of various biopolymers concerned with those biosynthesis processes are understood, and the advanced theory and method to the regulations of the reaction mechanism and the utilization in the field of biotechnology are lectured.

At first, students aim at the acquisition of nomenclature, the molecular structure of the biopolymer compound, and the higher order structure.
Then, Students learn understanding as the biochemical significance including the in vivo role of a nucleic acids, proteins,and the carbohydrate chains.
Finally, Students assume that understand a utilization of each biopolymer for biotechnology.

Student learning outcomes

By the end of this course, students will be able to:
1. Understand the In vivo optical imaging of tumor progression in mouse models.
2. Understand the Asymmetric intramolecular aldol condensation.
3. Understand theComputer modeling of biomolecules and reactions of proteins and metals.

Keywords

Bioimaging, Chiral molecule, Condensation, Computer modeling, Protein

Competencies that will be developed

Intercultural skills Communication skills Specialist skills Critical thinking skills Practical and/or problem-solving skills
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Class flow

This course is held over two academic quarters. The written report must be submitted by a date specified. Students must read each part of the given experiment and prepare a procedure flow in advance to understand about the experiment and to ensure safety and smooth running.

Course schedule/Required learning

  Course schedule Required learning
Class 1 In vivo optical imaging of tumor progression in mouse models #1 Students will learn basic techniques for in vivo optical imaging using a mouse tumor model through construction of a reporter gene, gene transduction into mammalian cells and animal experiments
Class 2 In vivo optical imaging of tumor progression in mouse models #2 Students will learn basic techniques for in vivo optical imaging using a mouse tumor model through construction of a reporter gene, gene transduction into mammalian cells and animal experiments
Class 3 In vivo optical imaging of tumor progression in mouse models #3 Students will learn basic techniques for in vivo optical imaging using a mouse tumor model through construction of a reporter gene, gene transduction into mammalian cells and animal experiments
Class 4 In vivo optical imaging of tumor progression in mouse models #4 Students will learn basic techniques for in vivo optical imaging using a mouse tumor model through construction of a reporter gene, gene transduction into mammalian cells and animal experiments
Class 5 In vivo optical imaging of tumor progression in mouse models #5 Students will learn basic techniques for in vivo optical imaging using a mouse tumor model through construction of a reporter gene, gene transduction into mammalian cells and animal experiments
Class 6 Asymmetric intramolecular aldol condensation ¬— constructing CD-ring of steroids — #1 "Students will be able to: experience a process of optimizing conditions for synthetic organic reactions and understand characteristics of analytical methods for optically active compounds.
Class 7 Asymmetric intramolecular aldol condensation ¬— constructing CD-ring of steroids — #2 Students will be able to: experience a process of optimizing conditions for synthetic organic reactions and understand characteristics of analytical methods for optically active compounds.
Class 8 Asymmetric intramolecular aldol condensation ¬— constructing CD-ring of steroids — #3 Students will be able to: experience a process of optimizing conditions for synthetic organic reactions and understand characteristics of analytical methods for optically active compounds.
Class 9 Asymmetric intramolecular aldol condensation ¬— constructing CD-ring of steroids — #4 Students will be able to: experience a process of optimizing conditions for synthetic organic reactions and understand characteristics of analytical methods for optically active compounds.
Class 10 Asymmetric intramolecular aldol condensation ¬— constructing CD-ring of steroids — #5 Students will be able to: experience a process of optimizing conditions for synthetic organic reactions and understand characteristics of analytical methods for optically active compounds.
Class 11 Computer modeling of biomolecules #1 Understand the electronic structures of biomolecules through their molecular orbital calculations.
Class 12 Computer modeling of biomolecules #2 Understand the electronic structures of biomolecules through their molecular orbital calculations.
Class 13 Computer modeling of biomolecules #3 Understand the electronic structures of biomolecules through their molecular orbital calculations.
Class 14 Reactions of proteins and metals #1
Class 15 Reactions of proteins and metals #2 "Understand metal coordination and chemical reactions in the reaction space of proteins.

Textbook(s)

The experimental manuals for Biotechnology Laboratory I and II is distributed free of charge.

Reference books, course materials, etc.

Instructors will introduce reference books during the course.

Assessment criteria and methods

"Full attendance and completion of all experiments are compulsory.
Assessment is based on the quality of the written reports and on the status of submission thereof.
The instructor may fail a student if he/she repeatedly comes to class late or resubmits reports too often.
"

Related courses

  • Organic Chemistry I
  • Organic Chemistry II
  • LST.A203 : Biochemistry I
  • LST.A218 : Biochemistry II
  • Physical Chemistry I
  • Physical Chemistry II

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students must have successfully completed Basic Biotechnology Laboratory I and II.

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