2021 Advanced Separation Science

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Academic unit or major
Graduate major in Chemistry
Okada Tetsuo  Fukuhara Gaku 
Course component(s)
Lecture    (ZOOM)
Day/Period(Room No.)
Mon1-2()  Thr1-2()  
Course number
Academic year
Offered quarter
Syllabus updated
Lecture notes updated
Language used
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Course description and aims

This course teaches the fundamentals of separation required in various chemical studies. Molecular mechanisms that separation relies on, quantitative interpretation of separation processes, what causes good or poor separation etc will be theoretically considered based on physical phenomena including fluid mechanics and mass transfer as well as chemical interactions. This course enables students to overcome the problems that they will encounter in their own research work.

Student learning outcomes

By the end of this course, students will: 1. Know physics and chemistry involved in separation processes. 2. Understand the quantitative interpretation of results of separation. 3. Know dynamics and statics of separation processes. 4. Know how to improve separation performance. 5. Know that separation is not only a practical tool but also an efficient probe to the solution and interfacial phenomena


Two-phase distribution, Chromatography, Fluid mechanics, Electrostatic theory

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Students should answer exercise quiz related to the lecture during each class.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Molecular distribution in two phase systems Understand two phase distribution.
Class 2 Fundamentals of chromatography Understand fundamentals of chromatography.
Class 3 Parameters in chromatographic separation Understand quantitative description of chromatography with physical and chemical parameters.
Class 4 Characteristics of fluid flow Understand fluid flow based on fluid mechanics.
Class 5 Diffusion and mass transport Understand diffusion and mass transport.
Class 6 Electrostatic interpretation of ion exchange Interpret ion exchange phenomena based on electrostatic theory.
Class 7 Electrohporesis Introduce principle of electrophoresis.
Class 8 Weak interactions on separation Understand weak interactions on separation.
Class 9 Cooperativity on separation Understand effects on how cooperativity can be operative.
Class 10 Allosterism on separation Understand allosterism which can apply to separation.
Class 11 Thermodynamics on separation Understand advance thermodynamics which can apply to separation and analysis.
Class 12 Spectroscopies for separation Understand analyses for separated matters by means of spectroscopies.
Class 13 Excited-state analytical chemistry Understand ground- and excited-state separations.
Class 14 Chirality on separation Understand chiral chemistry on separation.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.



Reference books, course materials, etc.

Course materials are provided during class.

Assessment criteria and methods

Course scores are based on exercise quiz (100 %) .

Related courses

  • CHM.B331 : Quantitative Chemical Analysis
  • CHM.B202 : Basic Analytical Chemistry

Prerequisites (i.e., required knowledge, skills, courses, etc.)

No prerequisites are necessary, but enrollment in the related courses is desirable.

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