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2021　Advanced Organic Synthesis

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Academic unit or major
Graduate major in Chemistry
Instructor(s)
Ohmori Ken 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Mon3-4()  Thr3-4()  
Group
-
Course number
CHM.D432
Credits
2
Academic year
2021
Offered quarter
2Q
Syllabus updated
2021/3/19
Lecture notes updated
-
Language used
English
Access Index

Course description and aims

In early part of this course, the basic concept of retorsynthesis will be focused, and the latter half part will deal with several examples of multistep synthesis, particularly introducing synthetic approaches to natural products.

Student learning outcomes

At the end of this course, students will be able to have an understanding of basic concept of retrosynthesis and to learn about various synthetic tactics and strategies, enabling access to complex natural products.

Keywords

multistep synthesis
retrosynthesis
natural product synthesis

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills ✔ Practical and/or problem-solving skills

Class flow

Attendance is taken in every class.

Course schedule/Required learning

  Course schedule Required learning
Class 1 basic concept of retrosynthesis Exercise problems might be given in this class.
Class 2 functional group transformation in retrosynthesis Exercise problems might be given in this class.
Class 3 addition of a functional group for retrosynthesis Exercise problems might be given in this class.
Class 4 migratory functional group introduction in retrosynthesis Exercise problems might be given in this class.
Class 5 rearrangement concept in retrosynthesis Exercise problems might be given in this class.
Class 6 retrosynthesis based on cascade bond formation mechanism Exercise problems might be given in this class.
Class 7 retrosynthesis for chiral compounds Exercise problems might be given in this class.
Class 8 synthesis of caryophyllene Exercise problems might be given in this class.
Class 9 synthesis of cubane Exercise problems might be given in this class.
Class 10 synthesis of thromboxane A2 Exercise problems might be given in this class.
Class 11 synthesis of 1β-methyl carbapenem antibiotic Exercise problems might be given in this class.
Class 12 synthesis of ginkgolide Exercise problems might be given in this class.
Class 13 synthesis of taxol Exercise problems might be given in this class.
Class 14 synthesis of FK506 Exercise problems might be given in this class.
Class 15 Exercise for application problems Exercise problems might be given in this class.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

DAIGAKUIN-KOUGI II –Organic Chemistry–　(ISBN 9784807908219)

Reference books, course materials, etc.

DAIGAKUIN-KOUGI II –Organic Chemistry– (Exercise problems)

Assessment criteria and methods

Students’ course scores are based on final exams (ca. 70%), which will be held on site (not via online) and exercise problems (ca. 30%).

Related courses

  • CHM.D331 ： Organic Synthesis
  • CHM.D401 ： Basic Concepts of Organic Chemistry
  • CHM.D201 ： Organic Chemistry I
  • CHM.D202 ： Organic Chemistry II
  • CHM.D301 ： Organic Chemistry III

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students require basic knowledge of organic chemistry.

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